Immunotherapy in calves experimentally infected with cryptosporidium parvm

크립토스포리디움에 실험적으로 감염된 송아지의 면역요법

  • Wee, Sung-hwan (Research Coordination Division, Research Management Bureau, RDA) ;
  • Joo, Hoo-don (Research Coordination Division, Research Management Bureau, RDA) ;
  • Lee, Chung-gil (College of Veterinary Medicine, Chonnam National University) ;
  • Kim, Jong-taek (Veterinary Teaching Hospital, Kangwon National University) ;
  • Kang, Yung-bai (National Veterinary Research Institute)
  • Received : 1998.04.29
  • Published : 1998.06.25

Abstract

To determine the efficacy of immunotherapeutic agents, four female Holstein calves 7-day-old were inoculated per os with $1{\times}10^7$ C parvum oocysts (VRI-CN91). Each calf received twice daily oral dosage of 200-500ml of the immune bovine serum, immune bovine colostrum, mAb C6, and phosphate-buffered saline, respectively. Treatment was initiated 4 days postinfection and laster 3 days. The clinical sign of the calf treated with phosphate-buffered saline lasted 9 days after the initial treatment. The calves treated with those immunotherapeutic agents, however, showed decreased severity of diarrhea at day 3, 2, 5 after the initial administration, respectively. The calves treated with immunotherapeutic agents showed reduced parasite loads compared to control calf. These results suggest that oral passive immunotherapy with immune bovine colostrum and immune bovine serum may be a useful treatment approach.