The Protective Effect of Bifidobacterium breve K-110, K-111 and B. infantis K-525 on Carbon Tetrachloride-induced Hepatotoxicity in Rats

Bifidobacterium breve K-110, K-111 및 B. infantis K-525 균주의 사염화탄소 유발 간독성 보호 효과

  • Published : 1999.08.31

Abstract

The protective effect of Bifidobacterium breve K-110, K-111 and B. infantis K-525 on carbon tetrachloride induced hepatotoxicity in rats was investigated. Among them, B. infantis K-525 had the most potent hepatoprotective activity. It reduced serum aspartate aminotransferase and alanine aminotransferase levels to 51% and 80% of the $CCl_{4}-treated$ groups, respectively. In rat liver homogenate intoxificated with $CCl_{4}$, B. infantis K-525 inhibited in vitro as well as in vivo lipid peroxidation more than the other Bifidobacteria.

Keywords

Bifidobacterium spp.;hepatoprotective;lipid peroxidation