Effect of Dietary Soybean Hydrolysate on Plasma Lipid Profiles, Select Biochemical Indexes, and Histopathological Changes in Spontaneously Hypertensive Rats

대두가수분해물 유래 펩타이드 투여가 자발성 고혈압 흰쥐의 혈중 지질수준, 생화학적 지표 및 조직병리학적 변화에 미치는 영향

  • Chung, Sun-Wha (Department of Food and Nutrition, University of Ulsan) ;
  • Choi, Min-Ah (Department of Food and Nutrition, University of Ulsan) ;
  • Park, Jeong-Soon (Department of Food and Nutrition, University of Ulsan) ;
  • Kim, Kil-Soo (Institute of Asan Life Science Research Center) ;
  • Chung, Dae-Kyun (Institute and Department of Genetic Engineering, University of Kyunghee) ;
  • Nam, Hee-Sop (Research and Development Center, Nongshim) ;
  • Shin, Zae-Ik (Research and Development Center, Nongshim) ;
  • Yu, Ri-Na (Department of Food and Nutrition, University of Ulsan)
  • 정선화 (울산대학교 식품영양학과) ;
  • 최민아 (울산대학교 식품영양학과) ;
  • 박정순 (울산대학교 식품영양학과) ;
  • 김길수 (아산생명과학연구소) ;
  • 정대균 (경희대학교 유전공학과 및 유전공학 연구소) ;
  • 남희섭 (농심 상품개발연구소) ;
  • 신재익 (농심 상품개발연구소) ;
  • 유리나 (울산대학교 식품영양학과)
  • Published : 1999.08.31


Soybean (SoyPep) was prepared and evaluated their action on blood lipid profiles, select biochemical indexes and histopathological changes in spontaneously hypertensive rat (SHR). Male SHRs were divided into three groups and fed the experimental diet containing 0% (control), 3%, 10% SoyPep for 8 weeks. Lipids, antioxidative vitamin levels, glutamate oxaloacetate transaminase (GOT) and glutamate pyruvate transaminase (GPT) activities in plasma were measured, and angiotensin I converting enzyme (ACE) activities in kidney, vascular tissue and plasma were also measured. In addition, histopathological changes in various organs were investigated. Dietary SoyPep was effective for lowering plasma levels of triglyceride and LDL-cholesterol. ACE activities in aorta and kidney were decreased in the group fed SoyPep compared to control. There was no difference of plasma GOT and GPT activities, and no histopathological difference in various organs among the experimental groups. Our results suggest that SoyPep has beneficial effects on diseases such as hypertension and atherosclerosis. SoyPep could be useful to develop a novel functional safe food additive for preventing the chronic diseases.


soybean peptide;atherosclerosis;ACE activity