Short-term Oral Toxicity lest of the Pine Needle Extracts in Rat

솔잎추출물의 랫트에 대한 단기 급성경구 독성시험

  • Choi, Myong-Dal (The Korea Pharmaceutical Association) ;
  • Kim, Dong-Ho (Protein Function Research Unit, Korea Research Institute of Bioscience and Biotechnology) ;
  • Kim, Jae-Heung (Protein Function Research Unit, Korea Research Institute of Bioscience and Biotechnology) ;
  • Kim, Seung-Ho (Protein Function Research Unit, Korea Research Institute of Bioscience and Biotechnology)
  • Published : 1999.10.31

Abstract

The short-term toxicity tests of the pine needle extracts, which have been utilized for traditional remedies were examined. The pine extracts were injected into rats according to the method of intrastomachic administration at a dosage of 10 g/kg, and then the rats were brought up for 14 days. Following the period, death practice was not detected and $LD_{50}$ was calculated by >10 g/kg. And, there were no significant difference in the growth rate and histological observations compared to the control group. So, the pine extract was evaluated for safety reagent on rapid toxicity and side effect to the rat.

Keywords

Pine needle;toxicity