Anticancer Activity of Phytol and Eicosatrienoic Acid Identified from Perilla Leaves

들깻잎에서 동정된 Phytol과 Eicosatrienoic Acid의 암세포 증식억제 효과

  • 박건영 (부산대학교 식품영양학과 및 김치연구소) ;
  • 이경임 (양산대학 호텔조리과) ;
  • 이숙희 (부산대학교 식품영양학과 및 김치연구소)
  • Published : 1999.10.01


We investigated the inhibitory effects of phytol and methyl 11,14,17 eicosatrienoic acid (methyl ETA, n 3, 20 : 3) separated from perilla leaves on the growth of human cancer cells. Phytol inhibited significantly the growth of HT 29 human colon cancer cells, MG 63 osteosarcoma cells and AZ 521 gastric cancer cells. Although the activity of methyl ETA was lower than that of phytol, it was also observed to have the inhibitory effect on three human cancer cell lines. Furthermore, the DNA synthesis of the MG 63 osteosarcoma cells was markedly decreased by the addition of the phytol and methyl ETA. These results suggest that phytol and methyl ETA identified from the perilla leaves may play a role on the growth inhibition of the human cancer cells.


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