Anticancer Activity of Phytol and Eicosatrienoic Acid Identified from Perilla Leaves

들깻잎에서 동정된 Phytol과 Eicosatrienoic Acid의 암세포 증식억제 효과

  • 박건영 (부산대학교 식품영양학과 및 김치연구소) ;
  • 이경임 (양산대학 호텔조리과) ;
  • 이숙희 (부산대학교 식품영양학과 및 김치연구소)
  • Published : 1999.10.01

Abstract

We investigated the inhibitory effects of phytol and methyl 11,14,17 eicosatrienoic acid (methyl ETA, n 3, 20 : 3) separated from perilla leaves on the growth of human cancer cells. Phytol inhibited significantly the growth of HT 29 human colon cancer cells, MG 63 osteosarcoma cells and AZ 521 gastric cancer cells. Although the activity of methyl ETA was lower than that of phytol, it was also observed to have the inhibitory effect on three human cancer cell lines. Furthermore, the DNA synthesis of the MG 63 osteosarcoma cells was markedly decreased by the addition of the phytol and methyl ETA. These results suggest that phytol and methyl ETA identified from the perilla leaves may play a role on the growth inhibition of the human cancer cells.

References

  1. 식물대보감(자원편)
  2. J.Dugseong Women's Univ. v.7 Studies on the contents of inorganic compounds in Korean foods - the contents of sodium and potassium of fruits and vegetables Park, J.S
  3. Korean J.Nutr v.10 A study on oxalic acid and calcium content in Korean foods Kim, E.S.;Im, K.J
  4. Agric. Biol. Chem v.45 Anthocyanins and flavones in leaves and seeds of perilla plants Ishikura, N
  5. Agric. Biol. Chem v.53 Production of phenyl-propanoids from cultured callus tissue of the leaves of Akachirimen-shiso(Perilla sp.) Tamura, H.;Fujiwara, M.;Sugisawa, H
  6. Agric. Biol. Chem v.54 Structure of anthocyanins isolated from puple leaves of Perilla ocimoides L.var.crispa.Benth and their isomerization by irradiation of light Yoshida, K.;Kondo, T.;Kameda, K.;Goto, T
  7. Jap. J. Trop. Agric.(Nettai Nogyo) v.17 Distribution of oil glands, percentage yield of essential oil and its chemical composition in several shiso plants(perilla species) Morisada, S.;Yosida, T.
  8. Arch. Biochem. Biophys. v.276 Monoterpene biosynthesis : specificity of the hydroxylations of (-)-limonene by enzyme preparations from peppermint (Mentha piperita), spearmint (Mentha spicata) and perilla (Perilla frutescens) leaves. Karp, F.; Mihaliak, C. A.;Harris, J. L.;Croteau, R.
  9. Jap. J. Toxi. Envir. Health v.36 Determination of perilla ketone in perilla herb by capillary gas chromatograph/mass spectrometry Takano, I.; Yasuda, I.,;Hamano, T.;Seto, T.;Akiyama, K.
  10. J. Korean Soc. Food Nutr. v.21 Inhibitory effect of green-yellow vegetables on the mutagenicity in Salmonella assay system and on the growth of AZ-521 human gastric cancer cells. Park, K.Y.;Lee, K.I.;Rhee, S.H.
  11. J. Korean Soc. Food Nutr. v.22 Antimutagenic and antioxidative effects of perilla leaf extracts. Lee, K. I.;Rhee, S. H.;Kim, I. O.; Chung, H. Y.;Park, K. Y.
  12. J. Korean Soc. Food Nutr. v.21 Antimutagenic compounds identified from perilla leaf Lee, K. I.;Rhee, S. H.;Park, K. Y.;Kim, J. O.
  13. Pigments in vegetable Gross, J.
  14. J. Agric. Food Chem. v.37 Isolation of compounds with antimutagenic activity from Savoy Chieftain cabbage Lawson, T.;Nunnally, J.;Walker, B.;Bresnick, E.;Wheeler, D.;Wheeler, M.
  15. Inhibitory effects of green-yellow vegetables on the mutagenicity induced by various mutagens and on the growth of human cancer cells. Lee, K. I.
  16. Environ. Mutag. Carcin. v.13 Effects of phytol on the mutagenicity of UV and EMS in salmonella and Drosophila mutation assaying systems. Cho, Y. H.;Ahn, S. J.;Park, K. Y.;Yoo, M. A.;Lee, W. H.
  17. Korean J. Nutr. v.26 Antitumor activity of phytol identified from perilla leaf and its augmentative effect on cellular immune response Kim, K. H.;Chang, M. W.;Park, K. Y.;Rhee, S. H.;Rhew, T. H.;Sunwoo, Y. I.
  18. J. Korean Soc. Food Nutr. v.22 Effects of phytol and small water dropwort extract on the T subset in the sarcoma 180-transplanted mice Kim, K. H.;Chang, M. W.;Park, K. Y.;Rhee, S. H.;Rhew. T H.;Sunwoo, Y. I.
  19. Life Sciences v.50 Effects of olfactory stimulation with jasmin and its component chemicals on the duration of pentobarbital-induced sleep in mice Tsuchiya, T.;Tanida, M.;Uenoyama, S.;Nakayama, Y.
  20. Planta Med. v.58 Antispasmodic activity of β-damascenone and E-phytol isolated from Ipomoea pescaprae Pongprayoon, U.;Baeckstrom, P.;Jacobsson, U.;Linstrom, M.;Bohlin, L.
  21. Biochem. J. v.257 Inhibition of $Ca^{2+}$-induced cytosolic enzyme efflux from skeleltal muscle by vitamin E and related compounds Phoenix, J.;Edwards, R. H.;Jackson, M. J.
  22. Cancer Res. v.49 Growth factor Production by human colon carcinoma cell lines Anzano, M. A.;Rieman, D.;Prichett, W.;Bowen-Pope, D. F.;Greig, R.
  23. Cancer Res. v.48 Modulation of HT-29 human colonic cancer cell differentiation with calmidazolium and 12-O-tetradecanoylphorbol-13-acetate. Cecele, R. E.;Kedinger, M.;Haffen, K.
  24. J. Cell. Physiol. v.123 1α, 25- Dihydroxy vitamin D3 specific regulation of growth, morphology, and fibronectin and a human osteosarcoma cell line Franceschi, R. T.;James, W. M.;Zerlauth, G.
  25. Arch Biochem. Biophys v.176 Intestinal cytosol binders of 1,25-dihydroxyvitamin D₃and 25-hydroxyvitamin D₃ Kream, B. E.;Reynolds, R. D.;Knutson, J. C.; Eisman, J.;DeLuca, H. F.
  26. 식품과학과 산업 v.22 α-리놀레산(linolenic acid)의 생리기능 磯田 好弘;崔春彦
  27. Lipid biochemistry(4th ed.) Burr, M. I.;Harwood, J. L.
  28. Korean Biochem. J. v.13 인삼의 세포독성분획의 작용기작에 관한 연구(I)-인삼중의 petroleum ether 분획 이 동물암세포에서 고분자 물질의 합성에 미치는 영향 윤연숙;이세영;김병수;윤택구