Effects of Glucosamine Hydrochloride, Taurine and Their Combined Administration on Anti-inflammatory and Analgesic Action in Rats

흰쥐의 항염증 및 진통작용에 대한 Glucosamine Hydrochloride와 Taurine 및 그 혼합 투여시의 효과

  • Published : 1999.10.01

Abstract

The purpose of this study was to see the effect of anti inflammatory and analgesic action of the glucosamine hydrochloride(GA HCl) or taurine. Male Sprague Dawley rats(100~250g) and ICR mice(20 ~30g) were used. Experimental groups were divided into seven groups, one control group given as saline and six groups given as oral administration of GA HCl or taurine; GA HCl 250mg/kg, b.w group, taurine 250mg/kg, b.w group, GA HCl 250mg/kg, b.w+taurine 250mg/kg, b.w group, GA HCl 500mg/kg, b.w group, taurine 500mg/kg, b.w group, GA HCl 500mg/kg, b.w+taurine 500mg/kg, b.w group. Carrageenan induced edema test were shown to be significantly inhibited in the GA HCl 250mg/kg group and taurine 250mg/kg group compared to the control group, but the GA HCl 500mg/kg+taurine 500mg/kg group were significantly inhibited than the control group. Capillary permeability test were shown to be sig nificantly inhibited in the taurine 500mg/kg group, but the GA HCl 500mg/kg+taurine 500mg/kg group were significantly inhibited than the control group. Leucocyte emigration test were shown to be significantly inhibited in the GA HCl 250mg/kg+ taurine 250mg/kg group and GA HCl 500mg/kg+taurine 500mg/kg group compared to the control group. Acetic acid, Phenyl p benzoquinone writhing syndrome were shown to be significantly inhibited in the GA HCl 500mg/kg+taurine 500mg/kg group compared to the control group. Inhibitory action against COX 1 and COX 2 were not significantly inhibited in the experimental group. These results suggest that the combined administration of the GA HCl and taurine have potential action in anti inflammatory and analgesic action.

References

  1. Immunology : An introduction inflammation. 2nd ed. Tizard, I. R.
  2. Pathophysiology(Diagnosis and Pharmacother) Kim, C. J.
  3. Ann. Rheum. Dis. v.34 Human arthritis applied to animal models. Towards a better therapy Willoughby, D. A.
  4. Current Medical Research and Opinion v.7 Glucosamine Sulphate for the management of arthrosis : a controlled clinical investigation Crolle, G. M. D.;Este, E. D. M. D.
  5. Pharmatherapeutica v.3 Oral glucosamine sulphate in the management of arthrosis : report on a multicentre open investigation in sportugal. Macario, J.T.;Italo, C.R.;Angelo, A.B.
  6. Current Medical Research and Opinion v.8 Double-blind clinical evaluation of the relative efficacy of ibuprofen and glucosamine sulphate in the management of osteoarthritis of the knee in outpatients. Vaz, L. A.
  7. Arzneim.-Forsch./Drug Res. v.4 Pharmacokinetics of glucosamine in man Setnikar, I.;Palumbo, R.; Canali, S.;Zanolo, G.
  8. Arzneim-Forsch./Drug Res. v.44 Efficacy and safety of intramuscular glucosamine sulfate in osteoarthritis of the knee Rechelt, A.;Forster, K. K.;Fischer, M.;Rovati, L. C.;Setnikar, I.
  9. Int. J. Tissue React. v.14 Antireactive properties of "chondro protective" drugs Setnikar, I.
  10. Japanes J. Clinical Nutrition v.20 The treatment effect of glucosamine-HCI on osteoarthritis (in japanese) Kajimoto, O.;Sakamoto, K.;Takamori, T.;Kajitani, N.
  11. Food Style v.21 The protective and improvement effect of glucosamine on osteoarthritis (in japanese) Suguro, S.
  12. Food Style v.21 A special quality and applied on glucosamine (in japanese) Sakamoto, K.
  13. Chitin. Chitosan Research v.4 Glucosamine for osteoarthritis (in japanese) Sakamoto, K.;Takamori, Y.
  14. Arzneim.-Forsch./Drug Res. v.41 Antireactive properties of glucosamine sulfate Setnikar, I.;Pacini, M. A.;Revel, L.
  15. Arzneim.-Forsch./Drug Res. v.41 Antiarthritic effects of glucosamine sulfate studied in animal models. Setnikar, I.;Pacini, M. A.;Revel, L.
  16. Adv. Pediatr. v.32 Taurine : Its biological role and clinical implications Chesney, R. W.
  17. Med. Biol. v.52 Its taurine an inhibitory neurotransmitter? Oja, S. S.;Lahdesmaki, P.
  18. Taurine and neurological disorders v.201 Modulating role of taurine on release of neurotransmitters and calcium in excitable tissue. Kuriyama, K.;Muramatsu, M.;Nakagawa, K.;Kakita, K.;Barbeau, A.(ed.);Huxtable, R. J.(ed.)
  19. Fed. Proc. v.39 Taurine as a neuromodulator Kuriyama, K
  20. Biochim. Biophys. Acta v.323 Effect of taurine on a muscle intracellular membrane Huxtable, R.;Bressler, R.
  21. Diabetologia v.36 Osmotically-induced nerve taurine depletion and the compatible osmolyte hypothesis in experimental diabetic neuropathy in the rat Stevens, M. J.; Lattimer, S. A.;Kamijo, M.;Van-Huysen, C.;Sima, A. A.;Greene, D. A.
  22. Science v.188 Retinol degeneration associated with taurine deficiency in the cat Hayes, K. C.; Carey, R. E.;Schmidt, S. Y.
  23. Ann. Rev. Biochem. v.55 Taurine : Biological update Wright, C. E.;Tallen, H. H.;Lin, Y. Y.;Gaull, G. E.
  24. Biochem. J. v.256 The antioxidant action of taurine, hypotaurine and their metabolic precursors Aruoma, O. I.;Halliwell, B.;Honey, B. W.;Butler, J.
  25. J. Pharm. Exp. Ther. v.277 Procollagen gene expression is down-regulated by taurine and niacin at the transcriptional level in the bleomycin hamster model of lung fibrosis Gurujeyalakshmi, G.;Lyer, S. N.;Hollinger, M. A.;Giri, S. H.
  26. Biochem. Soc. Trans. v.19 Influence of taurine and a substituted taurine on the respiratory burst pathway in the inflammatory respones Maloughlim, D. M.;Stapleton, P P;Bloomfield, F. J.
  27. Taurine in health and disease Taurine protects against oxidant induced lung injury possible mechanisms of action Schuller-Levis, G.;Quinn, M. R.;Wright, C.;Park, E.;Huxtable, R.(ed.)
  28. Taurine 2 Protective effect of taurine on indomethacin-induced gastric mucosal injury. Kim, S. M.;Kim, H. K.;Yang, W. B.;Kim, B. K.;Huxtable, R. (ed.);Azuma, J. (ed.);Kuriyama, K. (ed.);Nakagawa, M. (ed.);Baba, A.(ed.)
  29. Ir. J. Med. Sci. v.165 Neutrophil taurine in psoriasis. Stapleton, P. P.;Molley, A. M.;Rogers, S.;Bloomfield, F J.
  30. Proc. Soc. Exp. Biol. Med. v.1990 Effects of taurine on bleomycin induced lung fibrosis in hamsters Wang, Q.;Giri., S. N.;Hyde, D. M.;Nakashima, J. M.
  31. J. Pharm. Pharmacol. v.46 Effects of in-vivo administration of taurine and HEPES on the inflammatory response in rats Stapleton, P. P.;Mahon, T. M.;Nowlan, P.;Bloomfield, F. J.
  32. Proc. Soc. Exp. Biol. Med. v.111 Carrageenan induced edema in hind paw of the rats as an assay for anti-inflammatory drugs Winter, C. A.;Risley, E. A.;Nuss, G. W.
  33. Brit. J. Pharmacol. v.22 The use of change in capillary permeability in mice to distinguish between narcotic analgesics Whittle, B. A.
  34. Yakugaku Zasshi v.88 Studies on the mode of action of anti-inflammatory agents. I. Quantitative analysis of anti-inflammatory effect by Carboxymethyl cellulose pouch method Ishikawa, H.;Niinobe, C.;Tsurufuji, S.
  35. Arzneim. Forsch v.36 Pharmacological investigations of the new anti-inflammatory agent Tsurumi, K.;Mibu, H.;Okada, K.;Hasegawa, J.;Fujimura, H.
  36. Fed.Proc. v.18 Acetic acid for analgesic screening Koster, R.;Anderson, M.;Debeer, E. J.
  37. Brit. J. Pharmacol. v.25 Conditions influencing : the inhibition, by analgesic drugs, of the response to intraperitioneal injections of phenylbenzoquinone in mice Parks, M. W.;Pickens, J. T.
  38. Arch Int. Pharmacodyn. Ther. v.111 A method for measurement of analgesic activity on inflamed tissue Randall, L. O.;Selitto, J. J.
  39. J. Pharmacol. Exp. Ther. v.150 Reaction thresholds to pressue in edematous hindpawa of rats and responds to analgesic drugs Winter, C. A.;Flataker, L.
  40. Proc. Soc. Exp. Biol. Med. v.137 Auantial response in the Randall-Selitto assay Swingle, K. F.;Grant, T J.;Kvan, D. C.
  41. Natural Product Sciences v.3 Detection of antiinflammatory agents from natural products as inhibitors of cyclooxygenase I and ll Lee, D. H.;Kang, S. S.;Chang, I. M.;Mar, W. C.
  42. J. Pharmacol. v.40 Selectivity of neutrophil 5-lipoxygenase and cyclooxygenase inhibition by an antiinflammatory flavonoid glycoside and related aglycone flavonoids Moroney, M. A.;Alcaraz, M. J.; Folder, R. A.; Carey F.;Hoult, J. R. S.
  43. FEBS v.3 Characterization of ursolic acid as a lipoxygenase and cyclooxygenase inhibitor using machrophages, platelets and differentiated HL60 leukemic cells Najid, A.;Simon, A.;Cook, J.;Chable-Rabinovitch, H.;Delage, C.;Chulia, A. J.;Rigaud, M.
  44. Biochem. Biophys. Res. Commum. v.17 Froinflarnmatory cytokines regulate cyclooxygenase-2 mRNA expression in human macrophage Arias, N.S.;Keller, K.;Chadee, K.
  45. Biochem. Res. Commun. v.187 Lipopolysaccharide induces prostaglandin H synthase-2 in aveolar macrophage. O’Sullivan, M. G.;Huggins, E. M.;Meade, E.A.;Dewitt, D. L.;McCall, C. E.
  46. J. Biol. Chem. v.265 The aspirin and heme-binding sites of bovine and murine prostaglandin endoperoxide synthase. Dewitt, D. L.;El-Harith, E. A.;Kraemer, S. A.;Andrew, M. J.
  47. J. Path v.104 Studies of the mediators of the acute inflammatory response induced in rats in different sites by carrageenin and turpentine Rosa, M. D.;Giround, J. p.;Willoughby, D. A.
  48. Agents and Actions v.8 A comparison of air pouch sponge and pleurisy models of acute carrageenan inflammation in the rat Sedgwick, A. D.;Lees, P.
  49. Pharmacol. Rev. v.30 Pharmacology and endogeneous roles of prostaglndin endoperoxides, thromboxane A₂ and prostacyclin Moncada, S.;Vane, J. R.
  50. Proc. Natl. Acad. Sci. v.89 Human cyclooxygenase-2 CDNA Hla, T;Neilson, K.
  51. Biochem. Pharmacol. v.48 Selective inhibition of cyclooxygenase 2 Klein, T.;Nusimg, R. M.;Pfeilschifter, J.;Ullrich, V.
  52. Arthritis Rheum. v.37 Induction og cyclooxygenase 2 in human synovial microvessel endothelial cells by interleukin-1 Andrew, S.;Tariq, M.;William, W. C.;Mary, E. G.
  53. J. Lipid Med. v.6 A mitogen-inducible glucocorticoid-inhibited gene that encodes a second prostaglandin synthase/cyclooxygenase enzyme. Herschman, H.;Fletcher, B.;Kujubu, D.
  54. J. Lipid Med. v.6 Expression of the murine prostaglndin(PGH) synthase-1 and PGH synthase-2 isozymes in cos-1 cells Mede, E. A.;Smith, W. L.;Dewitt, D. L.