Synthesis of Novel 1,2-Diazepino[3,4-b]quinoxaline and Pyridazino[3,4-b]quinoxaline Derivatives

새로운 1,2-Diazepino[3,4-b]quinoxaline과 Pyridazino[3,4-b]quinoxaline

  • Kim, Ho Sik (Department of Chemistry, Catolic University of Taegu-Hyosung) ;
  • Jeong, Geuk (Department of Industrial Chemistry, Ulsan College)
  • 김호식 (대구효성가톨릭대학교 자연대 화학과) ;
  • 정극 (울산과학대학 공업화학과)
  • Published : 19990600


The 1,3-dipolar cycloaddition reaction of the quinoxaline 4-oxide 10 with 2-chloroacrylonitrile gave the 2,3-dihydro-lH-1,2-diazepino[3,4-blquinoxalines lla, b, respectively, which were converted into the 2,3,4,6-tetrahydro-lH-l,2-diazepino[3,4-b]quinoxaline 12. The reaction of compound lla with selenium dioxide in acetic acid/water resulted in ring transformation to give the 1,4-dihydro-4-oxopyridazino[3,4-blquinoxaline 13.



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