Distributions of Pefloxacin in Flounder

넙치에서의 Pefloxacin의 분포에 관한 연구

  • Received : 1998.09.24
  • Published : 1999.02.25

Abstract

This study showed the distribution of pefloxacin as a kind of quinolones after oral administrations of 100 mg/kg pefloxacin for 2 days in flounder. After administrations of pefloxacin, blood, muscle, and 8 organs including liver of flounder were analyzed by HPLC. In results, we knew that pefloxacin had absorbed from intestine and accumulated into gall bladder. In blood, maximum plasma concentration was showed $4.70{\mu}g/ml$ at 45min, and detected $0.31{\pm}0.01{\mu}g/ml$ at 11th day after administration. The concentration of pefloxacin was remained $0.29{\pm}0.02{\mu}g/g$ tissue in muscle at 10th day.

Keywords

pefloxacin;HPLC;flounder;fish

Acknowledgement

Supported by : 단국대학교

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