Multiphasic Analysis of Growth Curve of Body Weight in Mice

  • Kurnianto, E. (Faculty of Animal Sciences, Diponegoro Universiy) ;
  • Shinjo, A. (Faculty of Agriculture, University of the Ryukyus) ;
  • Suga, D. (Faculty of Agriculture, University of the Ryukyus)
  • Received : 1998.05.11
  • Accepted : 1998.11.26
  • Published : 1999.05.01


The present study describes the analysis of the multiphasic growth function (MGF) to body weight in laboratory and wild mice. Three genetic groups of laboratory mice (Mus musculus domesticus) designated $CF_{{\sharp}1}$, C3H/HeNCrj and C57BL/6NCrj, and a genetic group of Yonakuni wild mice (Mus musculus molossinus yonakuni, Yk) were used. Mean body weights of each genetic group-sex subclass from birth to 69 days of age taken at 3-day intervals were analyzed by a monophasic, diphasic and triphasic functions for describing growth patterns. A comparison among the three functions of the MGF was based on the goodness-of-fit criteria: residual standard deviation (RSD), adjusted R-square (Adj $R^2$) and Akaike's information criterion (AIC). Result of this study indicated that body weight averaged heavier for males than for females. Among the four genetic groups within both sexes, $CF_{{\sharp}1}$ showed the highest, subsequent followed by C3H/HeNCrj, C57BL/6NCrj and Yk. Comparison among the three functions revealed that the triphasic function was the best fit to growth data, with the lowest RSD, the highest Adj $R^2$ and the lowest AIC, for the four genetic groups. For the triphasic function, RSD within each genetic group-sex subclass was similar for males and females. Adj $R^2$ was 0.999 for all genetic group-sex subclasses. AIC for laboratory mice males and females ranged from -70.48 to 66.50 and from -92.81 to -68.64, respectively; whereas for Yk wild mice males was -74.29 and females -78.42.


Multiphasic Growth Function;Goodness-of-fit Criteria;Body Weight;Mice

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