Effects of Isoprothiolane administration on fat necrosis of Hanwoo(Korean Cattle) sire

한우 종모우의 지방괴사증에 대한 Isoprothiolane 투여효과

  • 이성수 (축협중앙회 개량사업본부 한우개량부) ;
  • 임연수 (축협중앙회 개량사업본부 한우개량부) ;
  • 정준 (축협중앙회 개량사업본부 한우개량부) ;
  • 장윤호 (축협중앙회 개량사업본부 한우개량부) ;
  • 박종관 (축협중앙회 개량사업본부 한우개량부) ;
  • 박노형 (축협중앙회 개량사업본부 한우개량부) ;
  • 원유석 (축협중앙회 개량사업본부 한우개량부) ;
  • 김상근 (충남대학교 수의과대학)
  • Received : 1999.03.09
  • Published : 1999.06.22


The effect of isoprothiolane(di-isopropyl-1,3-dithiolan-2-ylidenemalonate) aganist fat necrosis in Hanwoo(Korean Cattle) sire was evaluated. The 10 heads of Hanwoo sire suffering from fat necrosis were given 50mg/kg body weight of isoprothiolane(0.2g/kg of Fujix, Japan) orally once a day for 8 weeks. In 30% of these, the size of the necrotic fat masses had decreased significantly 7 months after the adminstration. Isoprothiolane did not affect on live body weight and semen characteristics. However the sire affected with fat necrosis had higher MCHC(Mean corpuscular hemoglobin concentration) than normal sire in hematologic values 10 weeks after administration. Number of RBC(red blood cell) and PCV(packed cell volume) 10 weeks after administration had been increased than those before administration(p < 0.05). The serum concentrations of creatinine, triglyceride, and total cholesterol 10 weeks after administration were higher than those before administration while the concentration of glucose was vice versa. The isoprothiolane may reduce the oxidation of glucose, increase the glucose transfer to lipids, and increase blood supply to necrotic masses. These results indicate that isoprothiolane may be useful as the therapeutic agent aganist fat necrosis.