Plasma Cholesterol-Lowering Effects of Alpiniae katsumadaii Extract as an Inhibiter of Pancreatic Cholesterol Esterase Activity

췌장 콜레스테롤 에스터레이즈 저해제인 초두구 추출물의 혈중 콜레스테롤 저해효과

  • 김희숙 (경성대학교 식품공학과) ;
  • 김지영 (경성대학교 식품공학과) ;
  • 최종원 (경성대학교 약학대학) ;
  • 허영미 (포항공과대학교 생명과학과) ;
  • 서판길 (포항공과대학교 생명과학과) ;
  • 류성호 (포항공과대학교 생명과학과)
  • Published : 2000.02.28

Abstract

Ethanol extract of Alpiniae Katsumadaii semen inhibited potently cholesterol esterase activity in vitro. Chloroform fraction of ethanol extract showed the stronger inhibitory effect than other solvent fractions-ethylacetate fraction, butanol fraction, and aqueous fraction. The chloroform frac ion of Alpiniae katsumadaii semen were studied as a candidator of plasma cholesterol lowering material in high cholesterol-fed rats. In high cholesterol-fed rats, the diet with chloroform fraction of 100 mg/kg and 150 mg/kg lowered not only plasma neutral lipids contents 25.9% and 26.5% but also plasma total cholesterol level 11.8% and 20.8%, respectively. Plasma HDL-cholesterol level and Atherogenic Index(AI) in Alpiniae chloroform fraction-fed rats were recovered as those level of normal rats.

Keywords

Alpiniae katsumadaii semen; cholesterol esterase;acyl CoA: cholesterol acyltransferase;Atherogenic Index