DOI QR코드

DOI QR Code

The Effect of Bee Venom Acupuncture into Chok-samni (ST36) on Neuronal Activity in the Spinal Cord

족삼리(足三里) 봉독약침자극(蜂毒藥鍼刺戟)이 척수내(脊髓內) Fos 양성반응(陽性反應) 신경세포(神經細胞)의 활성(活性)에 미치는 영향(影響)

  • Yim, Yun-Kyoung (Dept. of Acupuncture & Moxibustion Oriental Medical College, KyungHee University) ;
  • Kang, Sung-Keel (Dept. of Acupuncture & Moxibustion Oriental Medical College, KyungHee University) ;
  • Choi, Do-Young (Dept. of Acupuncture & Moxibustion Oriental Medical College, KyungHee University)
  • Published : 2000.07.30

Abstract

This study was designed to evaluate the analgesic effect of bee venom (BV) Acupuncture into different treatment points, Chok-samni (ST36) and blank loci of the gluteal muscle and back. We investigated neuronal activity in the spinal cord using the Fos immunohistochemical technique according to the pretreatment with different concentrations of BV, thirty minutes before the formalin injection. The results were summarized as follows: 1. The number of Fos-like immunoreactive (Fos-LI) neurons in L2 segment of the saline-formalin treated group was significantly increased in NECK and VENT of the spinal cord as compared with that of the room control group. However, there was no significant change in the number of the Fos-LI neurons in L2 segment of the BV-formalin treated group as compared with that of the room control group. 2. The number of Fos-LI neurons in L3-5 segment of the saline-formalin group was significantly increased in all the regions of 142 the spinal cord as compared with that of the room control group. However, the Fos-LI neurons in L3-5 segment of the BV-formalin treated group was dramatically decreased in all the regions of the spinal cord as compared with that of the saline-formalin group. Therefore, these results indicated that the BV acupuncture suppressed the nociceptive neuronal activities in L3-5 of the spinal cord induced by formalin injection. 3. There was a strong positive correlation between the formalin-induced pain behavior and the number of the Fos-LI neurons in L3-5 segment.

References

  1. 蜂毒療法과 蜂鍼療法 金文昊
  2. 人體生理學 金祐謙
  3. 奇蹟의 藥鍼療法 金廷彦
  4. 經穴學叢書 安榮基
  5. 鍼灸學 崔容泰(外)
  6. 痛症 카톨릭대학대학원
  7. 大韓藥典 제5개정 1,2부 해설 한국약학대학협의회
  8. 大韓韓醫學會誌 v.13 no.1 蜂鍼毒療法이 抗炎, 鎭痛 및 解熱에 미치는 效能에 關한 實驗的 硏究 高炯均
  9. 大韓鍼灸學會誌 v.10 no.1 蜂鍼毒 療法이 抗痙攣에 미치는 影響 孔賢淑
  10. 大韓鍼灸學會誌 v.14 no.2 蜂毒藥鍼刺戟이3-MCA 誘發 上皮腫에 對한 抗癌 및 免疫反應에 미치는 影響 權奇祿;高炯均;金容奭;朴英培;金昌煥;姜成吉
  11. 大韓鍼灸學會誌 v.14 no.2 蜂鍼療法의 最新 硏究動向에 對한 考察 金祉榮;高炯均;金容奭;朴英培;金昌煥;姜成吉
  12. 大韓鍼灸學會誌 v.15 no.1 蜂毒藥鍼療法의 抗炎症 作用에 關한 實驗的 硏究 金祉榮;高炯均;金容奭;朴英培;金昌煥;姜成吉
  13. 慶熙韓醫大論文集 v.15 中脘 및 足三里의 蜂毒療法이 鎭痛效果에 미치는 影響 李宗錫;權奇祿;高炯均
  14. 大韓韓醫學會誌 v.16 no.1 藥鍼用 蜂毒液의 局所毒性試驗에 對한 硏究 李宗錫;高炯均;金昌煥
  15. 中國醫學療法大全 麻仲學
  16. 中國鍼灸學發展史 莊育民
  17. 實用中醫辭典 朱文鋒
  18. 雲南中醫雜誌 張震
  19. Molecular Neurobiology Fos-Jun and primary genomic response in the nervous system;Possible physiological role and pathophysiological significance Doucet, S.P.;Squinto, S.P.;Bazan, N.G.;Bazan, N.G.(eds.)
  20. Physical Medicine and Rehabilitation Rehabilitation of patients with rheumatic disorders Nicholas, J.J.;Rush, R.J.;Braddom, R.L.(ed.)
  21. Venom of the Hymenoptera Piek, T.
  22. Brit. J. Pharmacol. A pepride from the venom of the honey Bee Assen, E.S.K.
  23. Nature v.245 An anti-inflammantory peptide from bee venom Billingham, M.E. https://doi.org/10.1038/245163a0
  24. J. Comp. Neurol. v.296 Expression of c-fos like protein as a maker for neuronal activity following noxious stimulation in the rat Bullitt, E. https://doi.org/10.1002/cne.902960402
  25. Neurosci. Lett. v.103 Application of the formalin test to the study of orofacial pain in the rat Clavelou, P.;Pajot, J.;Dallel, R.;Raboisson, P. https://doi.org/10.1016/0304-3940(89)90125-0
  26. Neurotic Lett. v.83 Subcutaneous formalin-induced activity of dorsal horn neurons in the rat dorsal horn neurons Dickenson, A.H.;Sullivan, A.F. https://doi.org/10.1016/0304-3940(87)90242-4
  27. Pain v.30 Subcutaneous fomalin-induced activity of dorsal horn neurons in the rat: differential response to an intrathecal opiate administered pre or post formalin Dickenson, A.H.;Sullivan, A.F. https://doi.org/10.1016/0304-3959(87)90023-6
  28. Pain v.4 The formalin test;a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats Dubuisson, D.;Dennis, S.G. https://doi.org/10.1016/0304-3959(77)90130-0
  29. Pain v.61 Dextromethorphan suppresses both formalin-induced nociceptive behavior and the formalin-induced increase in spinal cord c-fos mRNA Elliott, K.J.;Brodsky, M.;Hynansky, A.D.;Foley, K.M.;Inturrisi, C.E. https://doi.org/10.1016/0304-3959(94)00214-Y
  30. Neuroscience v.42 no.3 The Antinociceptive Action of Surpraspinal Opioids Results from an Increase in Descending Inhibitory Control: Correlation of Nociceptive Behavior and c-fos Expression Gogas, K.R.;Presley, R.W.;Levine, J.D.;Basbaum, A.I. https://doi.org/10.1016/0306-4522(91)90031-I
  31. Br. J. pharmacol. v.50 Anti-inflammantory property of 401(MCD-peptide), a peptide from the venom of the bee Apis mellifera Hanson, J.M. https://doi.org/10.1111/j.1476-5381.1974.tb09613.x
  32. Br. J. Pharmacol. v.90 After C-fibre and A-delta activity in models of inflammation Heapy, C.G.;Jamieson, A.;Russell, N.J.W.
  33. Nature v.328 Induction of c-fos like protein in spinal cord neurons following sensory stimulation Hunt, S.P.;Pini, A.;Evan, G. https://doi.org/10.1038/328632a0
  34. Brain Res. v.577 Electroacupuncture modifies the expression of c-fos in the spinal cord induced by noxious stimulation Lee, J.H.;Beitz, A.J.
  35. NeuroReport v.3 Nitric oxide mediates Fos expression in the spinal cord induced by mechanical noxious stimulation Lee, J.H.;Wilcox, G.L.;Beitz, A.J. https://doi.org/10.1097/00001756-199210000-00005
  36. J. Comp. Neurol. v.285 Expression of c-fos protein in interneurons and projection neurons of the rat spinal cord in response to noxious somatic, articular, and visceral stimulation Menetrey, D.;Gannon, A.;Levine, J.D.;Basbaum, A.I. https://doi.org/10.1002/cne.902850203
  37. Nature v.322 Role of ion flux in the control of c-fos expression Morgan, J.I.;Curran, T. https://doi.org/10.1038/322552a0
  38. Biochem. Biophys. Res. Comm. v.238 Melittin binds to secretory phospholipase A2 and inhibits its enzymatic activety Shamsher, S.S.;Peterson, J.W.;Chopra, A.K. https://doi.org/10.1006/bbrc.1997.7295
  39. Pain v.38 Modified formalin test;characteristic biphasic pain response Shibata, M.;Ohkubo, T.;Takahashi, H.;Inoki, R. https://doi.org/10.1016/0304-3959(89)90222-4
  40. J. Neurosurg. v.82 no.6 Mapping of dermatomes of the lower extremities based on an animal model Takahashi, Y.;Takahashi, K.;Moriya, H. https://doi.org/10.3171/jns.1995.82.6.1030
  41. Brain Res. v.535 Central nervous system plasticity in the tonic pain response to subcutaneous formalin injection Terence, J.;Anthony, C.;Vaccarino, L.;Melzack, R. https://doi.org/10.1016/0006-8993(90)91835-5
  42. Brit. J. Exp. Path. v.41 no.2 The affinity of reticuloendotherial systim for various serum proteins Thorbecke, G.J.
  43. Pain v.51 The formalin test;and evaluation of the method Tjolsen, A.;Berge, O.G.;Hunskaar, S.;Rosland, J.H.;Hole, K. https://doi.org/10.1016/0304-3959(92)90003-T