DOI QR코드

DOI QR Code

Effects of various Herbal Acupuncture on Adjuvant Arthritis in Rats

다양한 약침제제(藥鍼製劑)가 Rat의 Adjuvant 관절염(關節炎)에 미치는 영향(影響)

  • Ha, Jee-Yong (Dept. of Pathology, college of Oriental Medicine, Sang Ji UNIV) ;
  • Lee, Seon-Goo (Dept. of Pathology, college of Oriental Medicine, Sang Ji UNIV) ;
  • Yu, Byeong-Gil (Dept. of Pathology, college of Oriental Medicine, Sang Ji UNIV)
  • Published : 2000.12.30

Abstract

To investigate effects of vanous herbal-acupuncture, which were Daebangpungtang, Oyaksungisan, Dokhwalgisaengtang, and Binsosan on Adjuvant Arthritis in rats, the edema rate, the number of WBC, the quantity of TNF-${\alpa}$, COX -2, and IL-6, and histological test of the muscular tissue were measured in the arthritis part. After elicilating arthritis of Sprague Dawely(SD) rats by injection of Freund's complets adjuvant for 2 weeks, saline was injected for the control group, Daebangpungtang acua-acupuncture was injected for the Daebangpungtang group, Oyaksungisan acua-acupuncture was injected for the Oyaksungisan group, Dokhwalgisaengtang acua-acupuncture was injected for the Dokhwalgisaengtang group, and Binsosan acua-acupuncture was injected for the Binsosan group during 30days. Selected point was ST35 in all groups. 1. The number of WBC was $8.24{\pm}0.51$($10^3$/ml) in the normal group and $27.35{\pm}3.51$($10^3$/ml) in the control group. the Daebangpungtang group and the Oyaksungisan group decreased each $20.42{\pm}2.75$($10^3$/ml) and $19.78{\pm}4.99$($10^3$/ml) in the Exp.ll group. This fact showed that the group Exp.ll was more effective than the control group effectively. (P<0.05) 2. The volume of the paw were checked. The volume of paw was $0.62{\pm}0.11mm in the control group and $0.45{\pm}0.08$mm in the Daebangpungtang group and $0.47{\pm}0.07$mm in the Oyaksungisan group, the swelling of the paw was restricted significantly in the Daebangpungtang and Oyaksungisan group(P<0.05) 3. The bands of the TNF-${\alpa}$, COX -2 in the muscular tissue of the control group wcre certain and thick than other groups(except normal group), and the band of the IL-6 in the muscular tissue of all group(except normal group) were similar forms. 4. In histological finding, because of severe inflammatory reaction, remarkably irregular tissue and large amount of inflammatory cells were found in thc control and Dokhwalgisaengtang group. But the Oyaksungisan and Daebangpul1gtang group showed small amount of inflammatory cells, the refrained inflammatory state and even recovering state. From these results, it is showed Oyaksugisan and Daebangpungtang acua-acupuncturc refrain inflammatory reaction and muscular tissue necrosis in SD rats paw were induced by Freund's complete adjuvant

References

  1. J. Clin. Invest. v.97 no.11 Selective inhibition of cyclooxygenase(COX-2) reverse inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis Gary D. Anderson;Scott D. Haser;Kelly L. Mcgarity;Margaret E. Bremer;Peter C. Isakan;Susan A. Gregory https://doi.org/10.1172/JCI118717
  2. Inflamm Res v.45 The analgesic drug buprenorphine inhibits osteoclastic bone resorption in vitro, but is proinflammatory in rat adjuvant arthritis Hall, T.J.;Jagher, B.;Schaeublin, M.;Wiesenberg, I. https://doi.org/10.1007/BF02280995
  3. Experientia v.52 Involvement of H1 receptor in the central antinociceptive effect of histamine: pharmacological dissection by electrophysiological analysis Braga, P.C.;Soldavini, E.;Pecile, A.;Sibilia, V.;Netti, C. https://doi.org/10.1007/BF01922417
  4. Microbiology v.141 Major membrane protein and lipoprotein as highly variable immunogenic surface components and strain-specific antigenic marker of Mycoplasma arthritidis Martina Droesse;Gerhard Tangen;Iris Gummelt;Helga Kirchhoff;Leigh R. Washbum;Renate Rosengarten https://doi.org/10.1099/13500872-141-12-3207
  5. Proc. Natl. Acad. Sci. v.93 Systemic versus cartilage-specific cxpression of a type II collagen-specific T-cell epitope determines the level of tolerance and susceptibility to arthritis Vivianne Malmstrom;Erik Michaelsson;Haevald Burkharst;Ragnar Mattsson;Eero Vuorio;Rikard Holmdahl https://doi.org/10.1073/pnas.93.9.4480
  6. Chem. Pharm. Bull. v.44 no.3 Preparation and antirheumatoid activity of optically active 2-acetylthiomethyl-4-(4-methylphenyl)-4-oxobutanoic acid(KE-298) Kazuya Kameo;Kimiyo Takeshita;Yoshiko Yasuda;Keita Matsumoto;Kazuyuki Tomisawa https://doi.org/10.1248/cpb.44.602
  7. Clin. Exp. Immunol. v.103 Therapeutic effects of estradiol benzoate on development of collagen-induced arthritis(CIA) in the lewis rat are mediated via suppression of the humoral response against denatured collagen typeII(CII) Waksman, Y.;Hod, I.;Friedman, A.
  8. Infection and Immunity v.64 no.1 Vitamin A deficiency predispose to Staphylococcus aureus infection Wiedermann, U.;Tarkowski, A.;Bremell, T.;Hanson, L.A.;Kahu, H.;Dahlgren, U.I.
  9. 류마치스성 관절염 환자에 있어서 활액 분석에 대한 임상적 연구 구석일
  10. 류마치스성 관절염 환자에 있어서 활액과 혈청내 Ferritin 농도에 대한 연구 황득수
  11. 류마토이드 인자 양성인 류마티 양 관절염에서 혈청 C-반응성 단백의 의의 권경훈
  12. 관절염 환자에 있어서 혈청과 관절액의 단백분획 각 면역글로블린 및 유산 탈수소효소 Isoenzyme에 관한 연구 서정탁
  13. 한국인에서 류마토이드 관절염과 제II형 조직적합항원과의 연관성에 관한 연구 서정대
  14. 류마토이드 관절염 환자의 세포성 면역에 관한 연구 홍광표
  15. 斑猫藥針이 白鼠의 Adjuvant 관절염에 미치는 영향 이연경
  16. 梔子藥針이 白鼠의 Adjuvant 관절염에 미치는 영향 김락현
  17. 艾灸와 麝香, 牛黃, 態膽 藥針이 Adjuvant관절염에 미치는 영향 나창수
  18. 羌活湯 및 加味羌活湯이 鎭痛 效果와 Adjuvant 關節炎 白鼠에 미치는 影響 윤영희
  19. 防風湯이 Adjuvant 誘發 關節炎에 미치는 影響 신민식
  20. Carrageenan으로 유발된 관절염 활액막의 광학 및 전자현미경적 관찰 위성민
  21. 흰쥐에서 TypeII collagen으로 유발된 관절염의 임상양상 및 면역반응 박동준
  22. 한국의 류마티스 관절염 환자의 폐침범을 조기진단하는데 있어서의 면역학적 지표와 폐기능검사의 유용성 이동석
  23. 류마티스 관절염 환자의 자가임파구 혼합반응에서 말초혈액 T세포의 증식반응과 Cytokine의 생성 임순자
  24. CDR3 size spectratyping을 이용한 정상인과 류마티스 관절염 환자의 T 세포 수용체 Repertoire complexity 분석 장명호
  25. 침구학 상해중의학원
  26. 方藥合編解設 申載鏞(編)
  27. 韓醫學辭典 金賢濟;洪元植(編)
  28. 中醫內科學 上海中醫學院(編)
  29. 巢氏諸病源候論 巢元方
  30. 東垣十種醫書 李東垣
  31. 原本編註醫學人門 李정
  32. 景岳全書(上) 張介賓
  33. 中國醫學大辭典 謝觀(編)
  34. Harrison's 내과학 해리슨번역편찬위원회
  35. 病理學 大韓病理學會
  36. 재활의학 김진호;한태륜
  37. 병태생리학 김창종
  38. 東醫物理療法科學 林準圭;申鉉大
  39. 鍼灸學(上) 全國韓醫科大學 鍼灸 · 經穴學敎室(編)
  40. 임상병리파일 이귀녕;이종순
  41. 그림으로 본 면역학 하대유(編)
  42. 류마토이드 관절염 환자에 있어서 단세포 세포독성검사에 의한 자연 살세포의 작용기전 김계성
  43. 痺症治驗 婁多峰
  44. 세포 · 분자 면역학 김광혁(외20인譯)