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The Effect of Herb-acupunctures of Bojoongiggi-tang (Buzhongyiqi-tang), Ginseng Radix, and Astragali Radix on Immune Responses in Rats

보중익기탕(補中益氣湯), 인삼(人蔘) 및 황(黃)기 약침(藥鍼)이 MTX로 약침(誘發)된 백서(白鼠)의 면역기능저하(免疫機能低下)에 미치는 영향(影響)

  • Kim, Jung-Hun (Dept. of Meridianology, College of Oriental Medicine, Kyunghee University) ;
  • Park, Hi-Joon (Acupuncture and Meridianology, Dept. of Oriental Medical Science, Graduate School of East-West Medical Science, Kyunghee University) ;
  • Lee, Hyang-Sook (Acupuncture and Meridianology, Dept. of Oriental Medical Science, Graduate School of East-West Medical Science, Kyunghee University) ;
  • Lee, Hye-Jung (Acupuncture and Meridianology, Dept. of Oriental Medical Science, Graduate School of East-West Medical Science, Kyunghee University)
  • 김정헌 (경희대학교 한의과대학 경혈학교실) ;
  • 박히준 (경희대학교 동서의학대학원 한의과대학 침구경락학교실) ;
  • 이향숙 (경희대학교 동서의학대학원 한의과대학 침구경락학교실) ;
  • 이혜정 (경희대학교 동서의학대학원 한의과대학 침구경락학교실)
  • Published : 2000.12.30

Abstract

Objectives : To investigate the effects of herb-acupunctures of Qi tonification herbs or formula on the rat immune depression induced by an anticancer drug, methotrexate (MTX) Methods: Animals were divided into 5 groups; Normal control group was not given any treatment. Immune depression was induced by oral administration of 1mg/kg MTX b.i.d for 4 days in Control, Sample I, II, and III groups. We treated on CV 4 (Guanyuan) with saline, Bojoongiggi-tang (Buzhongyiqi-tang), Ginseng Radix and Astragali Radix herb-acupunctures in Control, Sample I, II, and Ill groups, respectively. In both blood and spleen, the assessment of CD4+ T-cell count, CD8+ T-cell count, CD4/CD8 T-cell ratio was performed. Results: Here we show that 3 herb- acupuncture groups have an influence, to some extent, on CD4+ and CD8+ T-cell counts and CD4/CD8 T-cell ratio in both blood and spleen. Astragali Radix herb-acupuncture, in particular, was found to have significantly increased CD4+ T-cell count in blood and CD4/CD8 T-cell ratio in blood and spleen. Conclusions: The results of this study suggest that herb-acupunctures of Bojoongiggi-tang (Buzhongyiqi-tang), Ginseng Radix and Astragali Radix may have an influence over rat immune depression induced by MTX.

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