Anti-Helicobacter pylori Activity of Bifidobacterium spp.

  • Bae, Eun-Ah (Department of Food and Nutrition, Kyung Hee University) ;
  • Kim, Dong-Hyun (College of Pharmacy, Kyung Hee University) ;
  • Han, Myung-Joo (Department of Food and Nutrition, Kyung Hee University)
  • Published : 2000.08.01


The inhibitory effects of different Bifidobacterium spp. on the growth of Helicobacter pylori (HP) were investigated. A significant suppression of HP growth occurred only when HP was inoculated onto a petri dish containing 0.1 mg/ml of Bifidobacterium spp. When HP was separately cultured with B. breve K-110, B. catenulatum K-309, B magnum K-311, B. magnum K-321, and B. cuniculi K-513, the urease activity was also inhibited by these Bifidobacterium spp. Therefore, it appears that these Bifidobacterium spp. excrete a heat-labile inhibitory component for HP growth into the culture medium. Although most organic acids produced by the Bifidobacterium spp. inhibited the growth of HP, the HP growth was not inhibited by the physiological concentrations of organic acids produced in bifidobacteria-cultured media. Accordingly, these results suggest that some Bifidobacterium spp. may produce antibiotic-like compounds (bacteriocins).


  1. Lancet v.1 Unidentified curved bacilli on gastric epithelium in active chronic gastritis Warren, J. R.;B. J. Marshall
  2. Gastroenterology v.102 Mechanism of gastric mucosal damage induced by ammonia Tsujii, M.;N. Kawano;S. Tsujii;H. Fusamoto;T. Kamada;N. Sato
  3. Infec. Immun v.59 Essential role of urease in pathogenesis of gastritis induced by Helicobacter pylori in gnotobiotic piglets Eaton, K. A.;C. L. Brooks;D. R. Morgan;S. Krakowka
  4. J. Microbiol. biotechnol. v.9 Synergistic inhibition of membrane ATPase and cell growth of Helicobacter pylori by ATPase inhibiytos Ki, M.-R.;S.-K. Yun;W.-J. Lim;B.-S. Hong;S.-Y. Hwang
  5. Lactic Acid Bacteria Lactic acid bacteria in health and disease Salminen, S.;M. Deghton;S. gorbach;S. Salmimen;A. von Wright(eds.)
  6. J. Clin. Microbiol. v.27 Lactobacillus acidophilus inhibits growth of Campylobacter pylori Bhatia, S. J.;N. Kochar;P. Abraham;N. G. Nair;A. P. Mehta
  7. J. Microbiol. Biotechnol. v.9 Lactobacillus acidophilus inhibits the Helicobacter pylori adherence Lee, Y.;E. Shin;J. Lee;J. H. Park
  8. Arch. Pharm. Res. v.21 Inhibitory effect of Bifidobacterium spp. isolated from a healthy Korean on harmful enzymes of human intestinal microflora Park, H.-Y.;E.-A. Bae;M.J. Han;E.-C. Choi;D. H. Kim
  9. J. Microbiol.Biotechnol. v.9 Protective effect of Bifidobacterium spp. on experimental colon carcinogenesis with 1,2-dimethylhydrazine Han, M. J.;H.-Y. Park;D.-H. Kim
  10. Biol. Pharm. Bull v.21 Anti-Helicobacter pylori activity of herbal medicines Bae, E.-A.;M. J. Han;N.-J. Kim;d.-H. Kim