The Effects of Shi-Quan-Dai-Bu-Tang and Its Ingredients on the Survival of Jejunal Crypt Cells and Hematopoietic Cells in Irradiated Mice

방사선 피폭 마우스에서 소장움세포 및 조혈세포 생존에 미치는 십전대보탕 및 구성단미의 영향

  • Jo, Sung-Kee (Team for Radiation Food Science and Biotechnology, Korea Atomic Energy Research Institute) ;
  • Yu, Young-Bub (Team for Radiation Food Science and Biotechnology, Korea Atomic Energy Research Institute) ;
  • Oh, Heon (College of Veterinary Medicine, Chonnam National University) ;
  • Kim, Se-Ra (College of Veterinary Medicine, Chonnam National University) ;
  • Kim, Sung-Ho (College of Veterinary Medicine, Chonnam National University)
  • 조성기 (한국원자력연구소 방사선식품.생명공학기술개발팀) ;
  • 유영법 (한국원자력연구소 방사선식품.생명공학기술개발팀) ;
  • 오헌 (전남대학교 수의과대학) ;
  • 김세라 (전남대학교 수의과대학) ;
  • 김성호 (전남대학교 수의과대학)
  • Published : 2000.02.01

Abstract

We performed this study to determine the radioprotective effects of Shi-Quan-Dai-Bu-Tang, as a prescription of traditional Oriental medicine, and its major ingredients. The jejunal crypt survival, endogenous spleen colony formation, and apoptosis in jejunal crypt cells were investigated in mice irradiated with high and low dose of ${\gamma}$-rays. The administration of danggui, baishaoyao, rensan, gancao or baifuling before irradiation protected the jejunal crypts (p<0.005). Shoudehuang, danggui, baishaoyao, rensan and huangqui increased the formation of endogenous spleen colony (p<0.05). Chuanxiong, baishaoyao, rensan and baifuling reduced the frequency of radiation-induced apotosis (p<0.05). The results indicated that the extracts of danggui, baishaoyao, rensan and baifuling may have radoprotective effects in mice irradiated with high and low dose of ${\gamma}$-rays. The radioprotective effect of the prescription, Shi-Qaun-Da-Bu-Tang, was not significant.

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