Chemoprevention Effect of Polyozellus multiplex, a Wild and Edible Mushroom

야생식용버섯인 까치버섯(Polyozellus multiplex)의 암예방 효과

  • Kim, Hyun-Jeong (Dept. of Food Science and Technology, Keimyung University) ;
  • Han, Jung (Dept. of Food Science and Technology, Keimyung University) ;
  • Yang, Eui-Joo (Dept. of Food Science and Technology, Keimyung University) ;
  • Lee, Kap-Rang (Dept. of Food and Nutrition, Yeungnam University) ;
  • Lee, In-Seon (Dept. of Food Science and Technology, Keimyung University)
  • 김현정 (계명대학교 식품가공학과) ;
  • 한정 (계명대학교 식품가공학과) ;
  • 양의주 (계명대학교 식품가공학과) ;
  • 이갑랑 (영남대학교 식품영양학과) ;
  • 이인선 (계명대학교 식품가공학과)
  • Published : 2000.02.01


Methanol extract and its fractions of Polyozellus multiplex inhibited the growth of several tumor cell lines and its water fraction showed a higher cytotoxicity effect on the human gastric carcinoma cell, SNU668 than on the other cell lines. The glutathione S-transferase (GSH) content was decreased by MNNG treatment but increased by adding Polyozellus multiplex water fractions. Also the activities of GSH and superoxide dismutase were increased by more the treatment of Polyozellus multiplex water fractions than by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) alone. Polyzellus multiplex water fraction cased significant reduction in the proliferating cell unclear antigen (PCNA) labelling index in the glandular stomach epithelium as compared with the value of MNNG alone.


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