The Effects of Shellfish Hydrolysates on Lipid Metabolism in Rats Fed High-Fat Diet

고지방식이를 급여한 흰쥐의 패류가수분해물 급여 효과

  • Published : 2000.06.01

Abstract

This study was conducted to investigate the effects of shellfish hydrolysate on lipid metabolism in rats fed high fat diet. Male Sprague-Dawley rate weighting approximately 110g were fed basal control diet, high fat diet and high fat diet plus 4 different shellfish hydrolyates for 4 weeks. The shellfish hydrolysates from the different sources, were oyster, hard-shelled mussel, little neck clam and march clam. After 4 weeks, serum GOT, GPT, ${\gamma}$-GTP, triglyceride and total cholesterol was significantly decreased in shellfish hydrolysates supplementation with high fat diet compared to basal control and high-fat group(p<0.05). The total lipid and cholesterol content in liver showed significant decrease(p, 0.05). There were no different in serum GPT, HDL-cholesterol, liver total cholesterol and lipid of rats between basal control diet and high-fat diet. The unsaturated fatty acids, specific components of shellfishes were a little components in shellfish hydrolysate as they were a low and not different among the groups and were most well reflected in liver and plasma. Considering digestive and absorptive process of in human body, it was assumed that the hypolipidemic effect of shellfish was not under the influence of unsaturated fatty acids but the other components, peptides, taurine and betaine and so on was detected in the process of hyperlipidemia induced by high-fat diet.

References

  1. A study of exploiting raw material of seasoning by using fish and shell Kim YM;Kim DS;Kim YD;Yang SE
  2. Bull Korean Fish Soc v.27 no.3 A study of exploiting raw material of seasoning by using fish and shell Kim WS;Bae TJ;Choi JD
  3. Seafoods oils in human and disease John EK
  4. Korean J of Nutr v.30 no.6 Effect of protein hydrolysate on blood and liver lipids in rats fed fat-enriched diet Lee YS;Park YH;O JH;Kim TJ;Lee HS
  5. Animal Sci Tech v.66 Effect dietary lysine & arginine addition on growth. Performance and serum cholesterol level in chickens Aoyama Y;Ohmura E;Kato T;Yosida A
  6. Nutrition Research v.14 no.11 Effect of dietary peptides on plasma lipids and mechanism studied in rats and mice Liu Asto MS;Takeichi Kina MS;Miyuki Sugiyama BS
  7. Agrc Biol Chem v.50 no.5 Involvement of post-digestion "hydrohobic' peptide" in plasma cholesterol-lowering effect of dietary plant proteins Kimikazu I;Kiyoshi S;Fumio I
  8. A study on fatty acid pattern in brain and liver tissues of developing chicken embryos Choi JH
  9. J Biol Chem v.226 A simple method for the isolation and purification of total lipid from animal tissues Folch JML;Sloan Stanley GH
  10. J Lipid Res v.27 Direct transesterification of all classes of lipid in one-step reaction Lepage G;Roy CC
  11. Lipids v.25 Fatty acid content of marine oil capsules Chee KM;Gang XJ;Rees DMG;Meydani M;Ausman L;Johnson J;Singuel EN;Schaefer E
  12. Effect of dietary fish oil and casein on lipid metabolism of plasma and tissues in young chicks Choi IS
  13. Nutrition Research v.11 Dietary cysteine/methionine ratios and taurine supplementation: Effect on rat growth, amino acids and bile acids Sarwar G;Peace RW;Botting HG
  14. Korean J Nutr v.31 no.8 The effect of dietary shellfish on lipid metabolism in rats fed high-fat supplement Kim EM;Kim YM;Choi JH
  15. Biochemistry v.30 Taurine-conjugated bile acid act as $Ca^{2+}$ ionophores Zimniak P;Radomonska A;Lester R
  16. Physiological effects of the taurine supplmented diet on rats fed on the high fat diet compared to spontaneous hypertensive rats Kim EJ
  17. J Nutr Sci Vitaminol v.35 Effect of dietary pantethine level on drug-metabolizing system in the liver of rats orally administered varying amounts of autoxidized linoleate Hiramatsu N;Kishida T;Natake M
  18. Br J Nutr v.68 The Influence of a fish oil high in docosahexaenoic acid on plasma lipoprotein and vitamin E concentration and haemostatic function in healthy male volunteers Sander TAB;Hinds A
  19. J of Animal Science v.33 Fatty acid composition of pork lipids as affected by basal diets, fat source and fat level Brook CC
  20. Am J Clin Nutr v.31 The influence of dietary mackerel oil on the condition of organs and on blood lipid composition in the young growing pig Ruiter A;Jongbloed AW;van Gent CM;Danse LHJC;Metz SHM
  21. Effects of polyunsaturated fatty acid diets on the fatty acid composition and vitamin E levels in the milk and the serum of the Hwang HJ
  22. Effect of DHA and environmental enrichment on brain fatty acid composition and acetylcholinesterase activity Kim MJ