Total Lipid, Total Cholesterol and Fatty Acid Composition in Colostrum from Mothers with Preterm Delivery and Pregnancy Induced Hypertension

조기분만과 임신성 고혈압 산모의 초유내 총지질, 총콜레스테롤 및 지방산 조정

  • 안홍석 (성신여자대학교 식품영양학과)
  • Published : 2000.03.01


In this study, total lipid and cholesterol contents and fatty acid composition of colostrum milk obtained from 30 normal mothers, 10 mothers who was delivered of preterm infant and 8 pregnancy induced hypertensive mothers were analyzed. While total cholesterol content in preterm colostrum was significantly lower than other groups (p<0.05), total lipid content was not different among three groups, ranged 2.24-.2.2g/dl. Composition of saturated fatty acide, such as lauric acid and myristic acid which are medium chain fatty acids in preterm milk were higher than those of normal-term and hypertensive mother's milk. There was no difference n total composition of polyunsaturated fatty acids and the rationh of $\omega$6/$\omega$3 among 3 group mother's colostrum, ranged 19.45-21.45% and 6.42-7.87, respectively. but the composition of arachidonic acid and DHA in colostrum of hypertensive mothers were significantly higher than those of normal and preterm mothers. These data indicates that gestational length and complications during pregnancy may change the lipid profile and fatty acid composition of hyman milk colosstrum.


  1. Pediatrics v.75 Nutritional needs of low-birth-weght infants Committee on Nutrition, American Academy of Pediatrics
  2. J Pediatr v.99 Human milk feeding in premature infants: Protein, Fat and Carbohydrate balances in the first weeks of life Atkonson SA;Bryan MH;Anderson GH
  3. N Engl J Med v.308 Growth and biochemical response of protein infants fed human milk or modified infant fomula Gross SJ
  4. J Pediatr v.102 Marcromineral balances in premature infants fed thier own mother's milk or formula Atkinson SA;Radde IC;Anderson GH
  5. Pediatrics v.66 Development of functional response in human exocrine pancreas Lebenthal E;Lee PC
  6. Acta Pediatr Scand(Suppl) v.299 Fat absorption in the new bone Harries JT
  7. Pediatr Clin North Am v.32 Infant feeding: Formula, solids Barness LA
  8. Nutrition Today v.23 no.2 ω-3 fatty acids in growth and development and in health and disease Simopoulos AP
  9. Korean J Obstet Gynecol v.37 Study of maternal motality Yoo BH;Son YS
  10. Pregnancy and associated nutritional problems. In: Development Nutrition Pregnancy and associated nutritional problems Kretchmer N;Zimmermann M
  11. J Nurse Midwifery v.35 Role of nutrition in prevention of preeclampsia-Review of the literature Newman V;Fullerton JT
  12. Korean J Obstet Gynecol v.31 Change in content of 6-Ketoprostaglandin $F_{1\alpha}$,thromboxane B₂,prostaglandin E₂in mother of pregnancy induced hypertensive and color blood Jeon SH
  13. J Clin Endocrinol Metab v.46 Effect of prostaglandin synthetase inhibitors on pressor response to angiotensin in human pregnancy Everett RB;Worley RJ;MacDonald PC
  14. Am J Clin Nutre v.32 Diet-related toxemia in pregnancy: I Fat, fatty acids and cholesterol Chung R;Davis H;Ma Y;Naivkul O;Williams C;Wilson K
  15. Obstet Gynecol v.24 Lipid metabolism in toxemia and normal pregnancy BacalaoEB;Kaunitz H;Joseph J;Mckay DG
  16. Am J Obstet Gynecol v.148 Serum arachidonic acid levels in normal and preeclamptic pregnancies Osbure PL;Williams PP;Johnson SB;Holman RT
  17. Lancet v.9 An altered ratio of 18 : 2(9,11) to 18 : 2(9,12) linoleic acid in plasma phospholipids as a possible perdictor of pre-eclampsia ErsKine KJ;Inversen SA
  18. Am J Obstet Gynecol v.164 Decreased levels of polyunsaturated fatty acids in preeclampsia Wang Y;Kay HH;Killam AP
  19. J Biol Chem v.226 A simple method for the isolation and purification of total lipids from animal tissue Folch J;Less MS;Stanily GH
  20. J Lipid Research v.14 Determination of cholesterol using o-phthalal-dehyde Rudel LL;Moriss MD
  21. J AOAC v.59 no.5 Sensitive colorimetric determination of cholesterol in dairy products Bachman KC;Lin JH;Wilcox CJ
  22. Standards methods for the analysis of oils, fats and derivatives Paquot C;Hautfenne A
  23. Pregnancy and nutrition. in: Development Nutrition Kretchmer N;Zimmermann M
  24. Korean J Nutrition v.24 no.2 A study on the lipids content in human milk Choi MH;Moon SJ;Ahn HS
  25. Korean J Nutrition v.27 no.3 Change in contents of total lipid, total cholesterol and fatty acid composition of preterm milk during lactation Ahn HS;Hong HJ
  26. Korean J Nutrition v.28 no.2 A comparative study on the composition of preterm and fullterm human milk in colostrum Lee YW;Moon SJ;Lee MJ;Moon HN;Hong SJ
  27. Am J Clin Nutr v.38 Comparison of lipid composition of breast milk from mothers of term and preterm infants Bitman NJ;Wood DL;Hamosh M;Hamosh P;Mehta NR
  28. Pediatr Res v.16 Differences in the composition of preterm and term human milk during early lactation Lemons JA;Moye L;Hall D
  29. Am J Clin Nutr v.34 Energy and macroutrient content of human milk during early lactation from mothers giving birth prematurely and at term Anderson GH;Arkinson SA;Bryan MH
  30. Lactation Nutritional aspects of human lactation Casey CE;Hambidge KM;Nevill MC;Neifert MR(ed.)
  31. Korean J Nutrition v.26 no.6 A longitudinal study of the total lipid, total cholesterol and Vitamin E contents and fatty acids composition of human milk Moon SJ;Ahn HS;Lee HJ;Kim JH;Kim CJ;Kim SY
  32. Pediatr Res v.22 Increase in plasma phospholipid docosahexaenoic acids and eicosapentaenoic acids as a reflection of their intake and mode of administration Liu CF;Carlson SE;Rhodes PG;Rao VS;Meydrech FF
  33. Am J Clin Nutr v.40 The composition of preterm milk of in relation to the degree of prematurity Lapag G;Gollet S;Bougle D;Kien LC;Lepage D;Dallaire L;Darling P;Roy CC
  34. J Pediatr v.86 Correction of the malabsorption of the preterm infant with a mediaum chain triglyceride formula Roy CC;Ste Marie M;Chartrand L;Weber A;Bard H;Doray B
  35. Pediatrics v.55 Medium chain triglyceride feeding in premature infants: Effect on fat and nitrogen absorption Tantibhedhyangkul P;Hashim SA
  36. J Pediatr v.93 Fatdigestion in the stomach of premature infants Hamosh M;Sivasubramanian KN;Salzman Mann C;Hamosh P
  37. Pediatr Res v.13 Early postnatal nutrition and later growth of low birth weight newborns Roy CC;Lepage G;Chartrand L;Fontaine A
  38. Pediatrics v.72 Nutrient and mineral retention and vitamin D absorption in low birth weight infants. The effect of medium chain triglycerides Huston RK;Reynolds JW;Jensen C;Buist NRM
  39. Am J Physiol v.244 Effects of medium chain triglyceride feeding on glucose homeostasis in the newborn rat Pegorier JP;Leturque A;Ferre P;Turlan P;Girard J
  40. Am J Clin Nutr v.29 The effect of dietary fatty acids and cholesterol on the milk lipids of lactating women and plasma cholesterol of breast-fed infants Potter JM;Nestel PJ
  41. Biochem Biophys Acta v.210 Lipoprotein lipase activity of adipose tissue and mammary tissue and plasma triglycerides in pregnant and lactating rats Hamosh M;Clary TR;Chernick S;Scew RO