Biological activities of some organometalic compounds as artificial nuclease

인공핵산 분해효소로서 몇 가지 유기금속 화합물들의 생물활성

  • Sung, Nack-Do (Division of Applied Biology & Chemistry, Biology.Environmental Chemistry, College of Agriculture, Chung-nam National University) ;
  • Kim, Dae-Whang (Korea Research Institute of Chemical Technology) ;
  • Kwon, Byung-Mok (Protein Regulator R.U., Korea Research Institute Bioscience and Biotechnology) ;
  • Kim, Tae-Young (Division of Applied Biology & Chemistry, Biology.Environmental Chemistry, College of Agriculture, Chung-nam National University) ;
  • Suh, Il-Hwan (Division of Basic Sciences. Physics, College of Natural Science, Chung-nam National University)
  • 성낙도 (충남대학교 농과대학 응용생물화학부) ;
  • 김대황 (한국화학연구소 신물질 연구부) ;
  • 권병목 (생명공학연구소 단백질조절연구부) ;
  • 김태영 (충남대학교 농과대학 응용생물화학부) ;
  • 서일환 (충남대학교 자연과학대학 기초과학부)
  • Published : 2000.03.31

Abstract

A series of transition metal complexes of 3,6-bis(6'-methyl-2'-pyridyl)pyridazine ($L^{1}$) and 3,6-bis(2'-pyridyl)pyridazine ($L^{2}$) as artificial nuclease, $1{\sim}8$ were synthesized. After determining of X-ray crystal structure, hydrolysis rate constants of phosphates, as DNA model compound and biological activities were confirmed. $L^{2}$-Zn(II) complex, 8 was shown the best hydrolysis rate constant. The $L^{2}$-Ni(II) complex, 5 and $L^{2}$-Co(II) complex, 6 showed the highest herbicidal activity against SCP (Scriptus Juncoids) with excellent tolerance to rice, ORY (Oryzae sativa L.). And the $L^{1}$-Co(II) complex, 2, $L^{1}$-Zn(II) complex, 4 and ligand ($L^{1}$ amp; $L^{2}$) displayed above 90% fungicidal activity against MAG (Magnaporthe grisea).