The changes of osteocalcin, bone-specific alkaline phosphatase, estrogen, IGF-I, Ca2+, P and bone mineral density on osteoporosis induced by ovariectomy in rats

흰쥐에서 난소제거술로 유발시킨 골다공증시 osteocalcin, bone- specific alkaline phosphatase, estrogen, IGF-I, Ca2+, P와 bone density의 변화

  • Kim, Nam-soo (College of Veterinary Medicine, Chonbuk National University) ;
  • You, You-soon (College of Veterinary Medicine, Chonbuk National University) ;
  • Kang, Chang-won (College of Veterinary Medicine, Chonbuk National University) ;
  • Choi, In-hyuk (College of Veterinary Medicine, Chonbuk National University)
  • Accepted : 2000.10.24
  • Published : 2000.12.20

Abstract

The aim of this investigation was to examine the effects of osteocalcin, bone-specific alkaline phophatase, estrogen, insulin-like growth factor-I (IGF-I), Ca, P and bone mineral density on osteoporosis induced by ovariectomy in rats. Female Sprague-Dawley 30 rats of three-forth's birth, weighing $215{\pm}10g$, were divided into two groups including the sham operation group(5 heads) and ovariectomy group(25 heads). They were fed normal diets for 2 weeks before the experimental operation and for 8 more weeks after operation. The level of osteocalcin, TALP, BALP, estrogen, bone mineral density and IGF-I were increased in experimental group, but a little increased in sham operation group at same period. The change of rates of osteocalcin, TALP, BALP, estrogen, bone mineral density and IGF-I were significantly higher in experimental group than sham operation group. $Ca^{2+}$ was not changed between two groups and P was significantly decreased in experimental group and Ca/P ratio was higher in experimental group than sham operation group. Body weights were increased in all two groups and growth rate per day was higher in experimental group than sham operation group. However, femur weight I body weight ratio was lower in experimental group than sham operation group.

Acknowledgement

Supported by : 전북대학교 생체안정성연구소