The radioprotective effects of Bu-Zhong-Yi-Qi-Tang and its major ingredients in irradiated mice

방사선 피폭 마우스에서 보중익기탕 및 구성단미의 효과

  • Kim, Sung-ho (College of Veterinary Medicine, Chonnam National University) ;
  • Oh, Heon (College of Veterinary Medicine, Chonnam National University) ;
  • Kim, Se-ra (College of Veterinary Medicine, Chonnam National University) ;
  • Jo, Sung-kee (Food Irradiation Team, KAERI) ;
  • Byun, Myung-woo (Food Irradiation Team, KAERI) ;
  • Shin, Dong-ho (College of Veterinary Medicine, Chonnam National University)
  • 김성호 (전남대학교 수의과대학) ;
  • 오헌 (전남대학교 수의과대학) ;
  • 김세라 (전남대학교 수의과대학) ;
  • 조성기 (한국원자력연구소 방사선 식품공학팀) ;
  • 변명우 (한국원자력연구소 방사선 식품공학팀) ;
  • 신동호 (전남대학교 수의과대학)
  • Accepted : 2000.03.13
  • Published : 2000.06.25

Abstract

We performed this study to determine the effect of Bu-Zhong-Yi-Qi-Tang, as a prescription of traditional Oriental medicine, and its major ingredients on jejunal crypt survival, endogenous spleen colony formation, apopotosis in jejunal crypt cells, lethality and hematological change of mice irradiated with high and low dose of Y-radiation. Bu-Zhong-Yi-Qi-Tang administration before irradiation protected the jejunal crypts (p<0.0001), increased the formation of endogenous spleen colony (p<0.05) and reduced the frequency of radiation-induced apoptosis (p<0.05). The survival rate and mean survival time of the groups treated with Bu-Zhong-Yi-Qi-Tang within 30 days after the treatment were far better than the irradiation control group. In the experiment on the effect of ingredients of Bu-Zhong-Yi-Qi-Tang, the result indicated that the extract of Rensan (Panax ginseng), Danggui (Angelica sinensis), Shengma (Cimicifuga heracleifolia) and Chaihu (Bupleurum falcatnosa) might have a major radioprotective effect. Although the mechanisms of this inhibitory effect remain to be elucidated, these results indicated that BU-Zhong-Yi-Qi-Tang might be a useful radioprotector, especially since it is a relatively nontoxic natural product. Further studies are needed to characterize better the protective nature of Bu-Zhong-Yi-Qi-Tang extract and its ingredients.

Acknowledgement

Supported by : 과학기술부