Experimental infection of Korean Neospora caninum isolates in mice

Neospora caninum 국내 분리주의 마우스 감염실험

  • Bae, Ji-seon (College of Veterinary Medicine, Seoul National University) ;
  • Kim, Jae-hoon (National Veterinary Research and Quarantine Service) ;
  • Hur, Kwon (College of Veterinary Medicine, Seoul National University) ;
  • Kim, Ki-suk (National Veterinary Research and Quarantine Service) ;
  • Hwang, Woo-suk (College of Veterinary Medicine, Seoul National University) ;
  • Choi, Yang-kyu (Korea Research Institute of Bioscience and Biotechnology) ;
  • Hyun, Byung-hwa (Korea Research Institute of Bioscience and Biotechnology) ;
  • Kim, Dae-yong (College of Veterinary Medicine, Seoul National University)
  • Received : 2000.02.25
  • Published : 2000.03.25

Abstract

This study was carried out to investigate the pathogenicity of Korea N caninum isolates, KBA-1 and KBA-2 on SCID mouse following 3 different routes of infection. NC-1 was served as reference isolate. The pathogenecity was evaluated by progression of clinical signs, histopathology and immunohistochemistry. Pathogenicity of KBA-2 appears to be stronger than that of KBA-1 but weaker than that of NC-1. Progress of clinical signs and lesion distribution and pattern of each isolates were similar when the isolates were infected either subcatareously or intraperitoneally. However, oral inoculation of tachyzoites failed to induce the infection.

Acknowledgement

Supported by : 농림부