Effect of carboxymethyl chitosan on postoperative intraperitoneal adhesion formation in the rat

Rat에서 carboxymethyl chitosan의 복강수술후 유착형성에 미치는 효과

  • Jang, Kwang-ho (College of Veterinary Medicine, Kyungpook National University) ;
  • Kwon, Yong-sam (College of Veterinary Medicine, Kyungpook National University) ;
  • Kim, Jung-eun (College of Veterinary Medicine, Kyungpook National University) ;
  • Kwon, Eun-ju (College of Veterinary Medicine, Kyungpook National University) ;
  • Oh, Tae-ho (College of Veterinary Medicine, Kyungpook National University) ;
  • Lee, Keun-woo (College of Veterinary Medicine, Kyungpook National University) ;
  • Jang, In-ho (College of Veterinary Medicine, Kyungpook National University)
  • 장광호 (경북대학교 수의과대학) ;
  • 권영삼 (경북대학교 수의과대학) ;
  • 김정은 (경북대학교 수의과대학) ;
  • 권은주 (경북대학교 수의과대학) ;
  • 오태호 (경북대학교 수의과대학) ;
  • 이근우 (경북대학교 수의과대학) ;
  • 장인호 (경북대학교 수의과대학)
  • Received : 2000.06.10
  • Published : 2000.09.25

Abstract

The aim of this study was to determine the effectiveness of carboxymethyl chitosan(CMC) solution on preventing intraperitoneal adhesions. In this study, 44 rats were divided into four groups ; an untreated control group and three experimental groups that were treated with 3 ml of 1, 2 or 3% CMC solution, respectively. The anti-mesenteric serosa of the ileum was exteriorized and then abraded in a standard manner by scraping with a scalpel blade to create homogenous petechial hemorrhagic surface over a $0.5{\times}1cm$ area. The adhesions were blindly assessed 2 weeks later by using a computerized tensiometer. The mean tensile strength(Newton) of formed adhesions was $2.48{\pm}0.88$ in control group, $1.86{\pm}0.56$ in the 1% CMC-treated group, $1.75{\pm}0.71$ in the 2% CMC-treated group and $1.55{\pm}0.60$ in the 3% CMC-treated group. The most favorable prevention against adhesion was achieved in the 3% CMC-treated group(p<0.01). We could conclude that CMC was effective on preventing the formation of postoperative small intestinal adhesions in the rat.