Effects of ${\beta}-glucan$ from Lentinus edodes and Hordeum vulgare on Blood Glucose and Lipid Composition in Alloxan-induced Diabetic Mice

표고버섯과 보리에서 추출한 ${\beta}-glucan$이 Alloxan 유발 당뇨 마우스의 혈당 및 지질 성분에 미치는 영향

  • Song, Ji-Young (Department of Food & Nutrition, Kyunghee University) ;
  • Yoon, Ki-Ju (Department of nursing science, Wonju National College) ;
  • Yoon, Hae-Kyung (Home Economics, Kyungwon Jr.College) ;
  • Koo, Sung-Ja (Department of Food & Nutrition, Kyunghee University)
  • Published : 2001.12.01

Abstract

Effects of ${\beta}-glucan$ from Lentinus edodes and hordeum vulgare on blood glucose and lipid composition were investigated. Diabetes mellitus was induced in male ICR mice by the injection of alloxan into the tail vein at a dose of 75 mg/kg. The ${\beta}-glucan$ were administered orally for 10 days and the normal and alloxan-control group were orally administered with saline. The body weight gain and food intake were monitored every day and plasma levels of glucose, triglyceride, total cholesterol, LDL-cholesterol were determined at last day. Also the weight of liver, heart, spleen and kidney were determined. The ${\beta}-glucan$ from Lentinus edodes and hordeum vulgure lowered significantly body weight gain in alloxan-induced diatetic mice (p<0.05) and plasma glucose levels compared to that of alloxan-control group. Plasma triglyceride level in B500 was lowered in alloxan-induced diabetic mice. The ${\beta}-glucan$ of hordeum vulgare lowered weight of liver significantly (p<0.05). In conclusion, it was assumed that ${\beta}-glucan$ from hordeum vulgare have anti-hyperglycemic and anti-obese effects by reducing body weight gain and decreasing serum glucose and triglyceride level.