Hepatic Encephalopathy in a Dog

개의 간성 뇌증

  • Published : 2001.09.01


Hepatic encephalophthy was diagnosed with serum chemistry, abdominal radiography and ultrasonography in a 2.6kg, 4 year-old maltese dog showing signs of hypersalivation, involutary spasm of facial muscles, ataxia, behavior abnormalities like dullness, sleep disorder, restlessness. In serum chemistry, the level of alanine transferase and aspartate trasferase was mildly elevated, ammonia was severely increased. On abdominal radio-graphs, the size of liver was mildly decreased. In ultrasonographic examination, diffuse lesion with hyperechoic change and decreased vasculature were seen in the hepatic region. But vascular abnormalities of liver were not observed. Drug and dietary therapy were undertaken and severities of clinical sign were alleviated.



  1. Clin Sci v.67 Supersensitivity of benzodiazepine receptors in hepatic encephalopathy due to fulminant hepatic failure in the rat: Reversal by a benzodiszepine antagonist Baraldi M;Zeneroli ML;Ventura E;Penne A;Pinelli G;Ricci R;Santi M
  2. J Vet Intern Med v.7 A retrospective study of 77 cats with severe hepatic lipidosis,1975-1990 Center SA;Crawford MA;Guida L;Erb HN;King J
  3. Semin Vet Med Surg v.5 Liver function test in the diagnosis of portosystemic vascular anomalies Center SA
  4. Hepatic Encephalopathy: Management with Lactulose and Related Carbohydrates Conn HO;Bircher J
  5. Textbook of small animal internal medicine(5th ed.) History, Physical Examinaon, and Signs of Liver Disease Jan Rothuizen;Hein P. Meyer:Ettinger SJ(ed.)
  6. Yale J Biol Med v.57 Pappas SC: The GABA hypothesis of the pathogenesis of hepatic encephalopathy: Current status Jone EA;Schafer DF;Ferenci P
  7. Small animal internal medicine(2nd ed) C. Guillermo couto: Clinical Manifestation of Hepatobilliary Disease Richard WN
  8. JAVMA v.166 Freedland RA: Hyperammonemia due to a urea cysle enzyme deficiency in 2 dogs Strombeck DR;Meyer DJ
  9. Br Med J v.218 Flumazenil: A benzodiszepine antagonist Whitwam JG