Analysis of Butyltin Compounds(mono-, di-, and tributyltin) in Human Blood

혈액 중의 주석화합물(MBT, DBT, TBT)의 분석과 농도에 관한 연구

  • Kim, Nam Sook (Ocean Environmental Climate Division, Korea Ocean Research and Develoment Institute) ;
  • Park, Dong Uk (Department of Environmental Health) ;
  • Oh, Jae Ryoung (Ocean Environmental Climate Division, Korea Ocean Research and Develoment Institute) ;
  • Shim, Woon Joon (Ocean Environmental Climate Division, Korea Ocean Research and Develoment Institute)
  • Received : 2001.02.05
  • Published : 2001.04.25


Butyltin compounds, including mono-(MBT), di-(DBT) and tributyltin(TBT) were analyzed in 44 human blood samples randomly collected from a hospital in "K" a city. Gas chromatograph equipped with flame photometric detector(FPD) was used to quantify the amounts of butylin compounds. Method detection limits(MDL) of this analytical method were 3.69ng Sn/g for MBT, 0.91ng Sn/g for DBT and 1.09ng Sn/g wet wt for TBT respectively. Standard reference material(SRM) containing of $1.3{\mu}g/g$ TBT as chloride was analyzed to check if this analytical results would be reliable. Recovery of about 90% was obtained through this analysis, indicating that the analytical method from butyltin compounds blood was reliable. The concentrations of butyltin compounds ranged MDL(<3.69) to 7.93ng Sn/g for MBT and 1.15 to 5.41ng Sn/g wet wt for DBT. Tributyltin was below detection limit in all samples. Detection limits of our results are lower than those reported by Kannan et al. who reported butyltin compounds in 33 human blood samples in the United States. Detection of MBT and DBT on blood sample implies that butyltin compounds could be absorbed through consumption of seafoods or exposure to food stuffs made of plastics and household items. Further study is needed to examine if butyltin compounds in blood can be reliably analyzed and used as intake index.



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