DOI QR코드

DOI QR Code

The Role of Neuropeptide Y in the Central Regulation of Grass Intake in Sheep

  • Sunagawa, K. (Department of Animal Physiology, Faculty of Agriculture, University of the Ryukyus) ;
  • Weisiger, R.S. (Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne) ;
  • McKinley, M.J. (Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne) ;
  • Purcell, B.S. (Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne) ;
  • Thomson, C. (Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne) ;
  • Burns, P.L. (Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne)
  • Received : 2000.03.22
  • Accepted : 2000.06.30
  • Published : 2001.01.01

Abstract

The physiological role of brain neuropeptide Y (NPY) in the central regulation of grass intake in sheep was investigated through a continuous intracerebroventricular (ICV) infusion of NPY at a dose of $5{\mu}g/0.2ml/hr$ for 98.5 hours from day 1 to day 5. Sheep (n=5) were fed for 2 hours once a day, and water and 0.5 M NaCl solution were given ad libitum. Feed intake during ICV NPY infusion increased significantly compared to that during ICV artificial cerebrospinal fluid (CSF) infusion. Water and NaCl intake during ICV NPY infusion remained unchanged. Mean arterial blood pressure (MAP) and plasma osmolality during ICV NPY infusion were not significantly different from those during ICV CSF infusion. On the other hand, plasma glucose concentration during ICV NPY infusion increased significantly compared to that during ICV CSF infusion. The results suggest that brain NPY acts as a hunger factor in brain mechanisms controlling feeding to increase grass intake in sheep.

Keywords

NPY;Brain;Grass Intake;Sheep

Cited by

  1. Changes in single-unit activity in the ventromedial hypothalamic nucleus of goats during feeding vol.77, pp.6, 2006, https://doi.org/10.1111/j.1740-0929.2006.00394.x
  2. Several subpopulations of neuropeptide Y- containing neurons exist in the infundibular nucleus of sheep: An immunohistochemical study of animals on different diets vol.444, pp.2, 2002, https://doi.org/10.1002/cne.10121