Control of swine respiratory disease using egg yolk antibodies III. Immunopropbylactic effect of IgY in mouse model

난황항체를 이용한 돼지 호흡기 질병 방제에 관한 연구 III. 마우스에서의 방어 효과

  • Shin, Na-Ri (Department of Infectious Diseases, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University) ;
  • Kim, Jong-man (Division of Bacteriology and Immunology, National Veterinary Research and Quarantine Service) ;
  • Yoo, Han-Sang (Department of Infectious Diseases, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University)
  • 신나리 (서울대학교 수의과대학 및 농생명 공학부) ;
  • 김종만 (국립수의과학검역원 세균과) ;
  • 유한상 (서울대학교 수의과대학 및 농생명 공학부)
  • Accepted : 2001.08.21
  • Published : 2001.09.25

Abstract

As an attempt to control respiratory disease in swine, specific immunologloblin Ys(IgYs) against bacterial pathogens of the diseases were produced and specificity of the IgYs was analysed with Western blot in the previous studies. In this studies, the immunoprotective effects of produced IgY were evaluated in the mice. Mice were challenged with minimal lethal doses of P multocida 3A and 4D, B bronchiseptica and A pleuropneumoniae serotype 2 after intraperitoneal administration of IgY and the protectivity by IgY was dose-dependent at the concentration of 100, 200 and 400 mg/ml. These results suggested that IgY could be a potential immunoprophylactic candidates against those pathogens in swine and apply and effective source of passive immunity for other disease in animals.