Experimental renal artery embolization with iohexol-ethanol and barium-ethanol in dogs

개에서 iohexol-ethanol 및 barium-ethanol을 이용한 실험적 신동맥 색전술

  • Hwang, Guk-jin (Department of Veterinary Radiology, College of Veterinary Medicine, Seoul National University) ;
  • Chang, Dongwoo (Department of Veterinary Radiology, College of Veterinary Medicine, Seoul National University) ;
  • Seo, Minho (Department of Veterinary Radiology, College of Veterinary Medicine, Seoul National University) ;
  • Jung, Joohyun (Department of Veterinary Radiology, College of Veterinary Medicine, Seoul National University) ;
  • Choi, Mincheol (Department of Veterinary Radiology, College of Veterinary Medicine, Seoul National University) ;
  • Yoon, Junghee (Department of Veterinary Radiology, College of Veterinary Medicine, Seoul National University)
  • 황국진 (서울대학교 수의과대학 방사선과학교실) ;
  • 장동우 (서울대학교 수의과대학 방사선과학교실) ;
  • 서민호 (서울대학교 수의과대학 방사선과학교실) ;
  • 정주현 (서울대학교 수의과대학 방사선과학교실) ;
  • 최민철 (서울대학교 수의과대학 방사선과학교실) ;
  • 윤정희 (서울대학교 수의과대학 방사선과학교실)
  • Accepted : 2001.08.28
  • Published : 2001.09.25

Abstract

The present study was performed to investigate the effect of iohexol-ethanol mixture and barium-ethanol mixture on the induction of transcatheter renal artery embolization in healthy 18 dogs, which were divided into two groups of 9 dogs and the 9 dogs were divided into 3 subgroups of 3 dogs. The renal artery embolization was undertaken unilaterally with the dose of 1.5, 2.0, and 3.0 ml/kg iohexol-ehtanol mixture and with the dose of 0.2, 0.4, and 0.8 ml/kg barium-ethanol mixture. And serum chemistry on 0, 1,3, 7, and 14 days, intravenous pyelography on 7days, angiography on 14 days, and histopathology on 14 days were evaluated. Serum BUN and creatinine concentration of two groups with iohexol-ethanol mixture and barium-ethanol mixture administration were mildly increased a t 1 day after injection of embolic materials and then returned to baseline. No significant changes in BUN and creatinine levels occurred in any of dogs. In all dogs with the dose of 1.5 ml/kg iohexol-ethanol mixture, the renal arteries were not embolized. All dogs with the dose of 3.0 ml/kg died. In all dogs with the dose of 2.10 ml/kg, the treated arteries were completely occluded. In barium-ethanol mixture administered group, the renal artery in one dog with the dose of 0.2 ml/kg was not embolized. In all dogs with the dose of 0.8 ml/kg, the renal arteries were completely embolized, but loac overembolization occured in two dogs. All animals with the dose of 0.4 ml/kg had effective embolization and no evidence of radiopaque barium opacity in systemic arteries distal to the renal-artery was found. All embolized kidneys were shrunk and decreased in size in gross examination and were shown diffuse necrosis in histopathologic examination. In the present study, renal arteries were embolized with the dose of 2.0 ml/kg iohexol-ethanol mixture or 0.4 ml/kg barium-ethanol mixture. And it is considered that the dose had a satisfactory embolic effect.

Acknowledgement

Supported by : Seoul National University