The radioprotective effects of radices herbs

대표적 근류 생약의 방사선 방호효과

  • Kim, Sung-ho (College of Veterinary Medicine, Chonnam National University) ;
  • Oh, Heon (College of Veterinary Medicine, Chonnam National University) ;
  • Kim, Se-ra (College of Veterinary Medicine, Chonnam National University) ;
  • Jo, Sung-kee (Food Irradiation Team, KAERI) ;
  • Byun, Myung-woo (Food Irradiation Team, KAERI) ;
  • Kim, Kil-soo (Hae-Eun Life Science Research Institute) ;
  • Lee, Jong-hwan (College of Veterinary Medicine, Chonnam National University) ;
  • Shin, Dong-ho (College of Veterinary Medicine, Chonnam National University)
  • 김성호 (전남대학교 수의과대학) ;
  • 오헌 (전남대학교 수의과대학) ;
  • 김세라 (전남대학교 수의과대학) ;
  • 조성기 (한국 원자력연구소 방사선 식품공학팀) ;
  • 변명우 (한국 원자력연구소 방사선 식품공학팀) ;
  • 김길수 (해은생명과학연구소) ;
  • 이종환 (전남대학교 수의과대학) ;
  • 신동호 (전남대학교 수의과대학)
  • Accepted : 2001.02.09
  • Published : 2001.03.20

Abstract

We performed this study to determine the effect of Jiegeng(Platycodon grandiflorum), Danggui(Angelica sinensis), Gancao(Glycyrrhiza glabla), Chaihu(Bupleurum falcatnosa), Shoudehuang(Rehmannia glutinosa), Huangqi(Satragalus membranaceus), Muxiang(Saussurea lappa), Yuanzhi(Polygala tenuifolia), Rensen(Panax ginseng) and Baishaoyao(Paeonia lactiflolia), as Oriental radices herbs, on jejunal crypt survival, endogenous spleen colony formation and apoptosis in jejunal crypt cells of mice irradiated with high and low dose of ${\gamma}-radiation$. Jiegeng(p<0.005), Danggui(p<0.0005), Gancao(p<0.005), Chaihu(p<0.05), Muxiang(p<0.05), Rensen(p<0.005) and Baishaoyao(p<0.005) were effective in intestinal crypt survival. Danggui(p<0.05), Chaihu(p<0.05), Shoudehuang(p<0.05), Huangqi(p<0.05), Rensan(p<0.005) and Baishaoyao(p<0.05) increased the formation of endogenous spleen colony. The frequency of radiation induced apoptosis was also reduced by pretreatment with Chaihu(p<0.05), Muxiang(p<0.005), Yuanzhi(p<0.05), Rensan(p<0.05) and Baishaoyao(p<0.05). Although the mechanisms of this effect remain to be elucidated, these results indicated that Danggui, Chaihu, Muxiang, Rensan and Baishaiyao might be a useful radioprotector, especially since it is a relatively nontoxic natural product.

Acknowledgement

Supported by : 과학기술부