Murine susceptibility to Avian pneumovirus (APV) of turkey origin

칠면조에서 분리된 Avian pneumovirus(APV)의 쥐의 감염성에 대한 연구

  • Shin, Hyun-Jin (College of Veterinary Medicine, University of Minnesota)
  • 신현진 (미네소타 수의과대학, Pathobiology과)
  • Accepted : 2001.12.03
  • Published : 2001.12.24

Abstract

The infectivity of an isolate of avian pneumovirus (APV) from turkeys to Balb/c mice was investigated to examine the transmission possibility to mammals. Three different age groups (3, 5 and 7 weeks old) were exposed by oculonasal route with a cell cultured APV of turkey origin. No clinical signs were observed from both APV-inoculated and commingled mice. However, all the tissue samples including blood from mice in the APV-inoculated group were positive for APV by polymerase chain reaction (PCR) up to 6 days postinoculation. At 14 days postinoculation, APV was not detected from blood samples by PCR, but sera showed the presence of APV-specific antibodies. In commingled mice, APV was detected from lung and rectal swap samples by PCR. These results suggest that an APV isolate from turkey could be transmitted to mice by direct contact or other ways.