Effects of the Fractions of Oryza sativa cv. Heugjinmi on Plasma Glucose and Lipid Levels in Streptozotocin-Induced Diabetic Rats

흑진미 과피 용매분획물 투여시 당뇨 유발 흰쥐의 혈당 및 혈중 지질함량에 미치는 영향

  • Chung, Ha-Sook (Department of Foods and Nutrition, Duksung Women's University) ;
  • Han, Hye-Kyoung (Department of Foods and Nutrition, Duksung Women's University)
  • 정하숙 (덕성여자대학교 자연과학대학 식품영양학과) ;
  • 한혜경 (덕성여자대학교 자연과학대학 식품영양학과)
  • Published : 2002.02.01

Abstract

We have investigated the effects of the solvent fractions from the aleurone layer of Oryza sativa cv. Heugjinmi on plasma glucose and lipid levels in streptozotocin-induced diabetic rats. Sprague-Dawley rats were divided into 6 groups, normal, diabetic control, and four experimental groups. Diabetes mellitus was induced by injection of streptozotocin(45 mg/kg body weight) into tail vein, and fraction of Oryza sativa cv. Heugjinmi was administered orally in experimental rats for 14 days. The body weight, glucose, cholesterol, HDL-cholesterol, triglyceride, free fatty acid level, and aminotransferase activities were analyzed. It was identified that acetone and anthocyanin fractions significantly reduced the levels of glucose, triglyceride, and free fatty acid in plasma of diabetic rats. And HDL-cholesterol levels of acetone and anthocyanin groups were higher than those of diabetic control group. From these data, it can be postulated that acetone and anthocyanin fractions might possess rather potent hypoglycemic and hypotriglyceridemic properties in streptozotocin-induced diabetic rats.

Keywords

Oryza sativa ca. Heugjinmi;diabetes;glucose level;lipid level

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