Determination of Hydrogen Peroxide Concentration by Portable Near-Infrared (NIR) System

근적외분광분석법을 이용한 과산화수소의 농도 측정

  • 임현량 (동덕여자대학교 약학대학) ;
  • 우영아 (동덕여자대학교 약학대학) ;
  • 장수현 (동덕여자대학교 약학대학) ;
  • 김경미 (동덕여자대학교 약학대학) ;
  • 김효진 (동덕여자대학교 약학대학)
  • Published : 2002.10.01

Abstract

This experiment was carried out to determine non-destructively the hydrogen peroxide concentration of 3% antiseptic hydrogen peroxide solutions by portable near-infrared (NIR) system. Hydrogen peroxide standards were prepared ranging from 0 to 25.6 w/w% and the NIR spectra of hydrogen peroxide standard solutions were collected by using a quartz cell in 1 mm pathlength. We found the variation of absorbance band due to OH vibration of hydrogen peroxide depending on the concentration around 1400 nm in the second derivatives spectra. Partial least square regression (PLSR) and multilinear regression (MLR) were explored to develop a calibration model over the spectral range 1100-1720 nm. The model using PLSR was better than that using MLR. The calibration showed good results with a standard error of prediction (SEP) of 0.16%. In order to validate the developed calibration model, routine analyses were performed using commercial antiseptic hydrogen peroxide solutions. The hydrogen peroxide values from the NIR calibration model were compared with the values from a redox titration method. The NIR routine analyses results showed good correlation with those of the redox titration method. This study showed that the rapid and non-destructive determination of hydrogen peroxide in the antiseptic solution was successfully performed by portable NIR system without very harmful solvents.

References

  1. 조창희, 김효진, 맹대영, 서상훈, 조정환 : 근적외선 분광분석법을 이용한 타우린의 정량 분석. 약학회지 42, 545 (1998)
  2. Corveleyn, S., Vandenbossche, G. M. and Romon, J. P. : Near-infrared (NIR) monitoring of $H_{2}O_{2}$ vapor concentration during vapor gydrogen peroxide (VHP) sterilisation. Pharm. Res. 14, 294 (1997) https://doi.org/10.1023/A:1012085702372
  3. Cho, S. Y., Kim, J. Y. and Rhee, C. : Determination of rancidity of soybean oil by near infrared spectroscopy. Journal of Near Infrared Spectroscopy 6, 349 (1998)
  4. Du, Y., Cariveau, M. J., Kalmus, G. W, Lu, J. Q. and Hu, X. H. : Experimental study of optical properties of porcine skin dermis from 900 to 1500 nm. Progressing Biomedical Optics and Imaging Optical Biopsy III 123, 184 (2000)
  5. Blanco, M., Coello, J., Eustaquio, A., Iturriaga, H. and Maspoch, S. : Development and validation of a methodfor the analysis of a pharmaceutical preparation by near-infrared diffuse reflectance spectroscopy. J. Pharm. Sci. 88, 551 (1999) https://doi.org/10.1021/js980338f
  6. Blanco, M., Coello, J., Eustaquio, A., Iturriaga, H. and Maspoch, S : Development and validation of methods for the determination of miokamycin in various pharmaceutical preparations by use of near infrared reflectance spectroscopy. Analyst 124, 1089 (1999)
  7. Blanco, M., Eustaquio, A., Gonzlez, J. M. and Serrano, D. : Identification and quantitation assays for intact tablets of two related pharmaceutical preparations by reflectance near-infrared spectroscopy: validation ofthe procedure. J. Pharmaceut. Biomed. 22, 139 (2000)
  8. Blanco, M., Coello, J., Iturriaga, H. and Maspoch, S. : Development and validation of near infrared method for the analytical control of a pharmaceutical preparation in three steps of the manufacturing process. Fresenius J. Anal. Chem. 368, 534 (2000) https://doi.org/10.1007/s002160000506
  9. Eistaquio, A., Graham, P., Jee, R. D., Moffat, A. C. and Trafford, A. D. : Quantification of paracetamol in intact tablets using near-infrared transmittance spectroscopy. Analyst 123, 2303 (1988)
  10. Trafford, A. D., Jee, R. D., Moffat, A. C. and Gaham, P. : A rapid quantitative assay of intact paracetamol tablets by reflectance near-infrared spectroscopy. Analyst 124, 163 (1999)
  11. Sekulic, S. S., Wakeman, J., Doherty, P. and Hailey P. A.: Automated system for the on-line monitoring of powder blending processes using near-infrared spectroscopy Part II. Qualitative approaches to blend evaluation. J. Pharmaceut. Biomed. 17, 1285 (1998)
  12. El-hagrasy, A. S., Morris, H. R., D'amico, F., Lodder, R. A. and Drennen III, J. K. : Near-infrared spectroscopy and Imaging for the morintoring of powder blend homogeneity. J. Pharm. Sci. 90, 1298 (2001) https://doi.org/10.1002/jps.1082
  13. Redenti, E., Peveri, T., Ano, M., Ventura. P., Gnappi, G. and Montenero, A.: A study on the differentiation between amorphous piroxicam: ${\beta}$-cyclodextrin complex and a mixture of the two amorphous components. Int. J. Pharm. 129, 289 (1996)
  14. Aditya, D. P., Pal, E. L. and Mark, S. K. : Quantitative analysis of polymorphs in binary and multi-component powder mixtures by near-infrared reflectance spectroscopy. Int. J. Pharm. 206, 63 (2000) https://doi.org/10.1016/S0378-5173(00)00530-5
  15. Giguere, P. A. and Chen, Hung: Hydrogen bonding in hydrogen peroxide and water. a raman study of the liquid state. J. Raman spec. 15, 199 (1984)