Comparison of Analytical Methods for DEHP Migration from PVC Bags for Blood Storage and Infusion; By Gas Chromatography and UV-vis Spectrophotometry

혈액·수액용 PVC 백에서 용출된 DEHP의 검출 분석 방법 비교; 기체 크로마토그래프와 분광 광도계

  • Kim, Jung Hwan (Department of Fiber & Polymer Engineering, Center for Advanced Functional Polymers, Hanyang University) ;
  • Kim, Seong Hun (Department of Fiber & Polymer Engineering, Center for Advanced Functional Polymers, Hanyang University) ;
  • Choi, Hyeong Ki (Biotechnology & Environmental Engineering Division, Agency for Technology and Standards) ;
  • Lee, Chang Hyung (Department of Medical Devices & Radiation Health, Korea Food & Drug Administration)
  • 김정환 (한양대학교 섬유고분자공학과) ;
  • 김성훈 (한양대학교 섬유고분자공학과) ;
  • 최형기 (기술표준원 생물화학기술표준부) ;
  • 이창형 (식품의약품안전청 의료기기평가부)
  • Received : 2001.10.22
  • Published : 2002.02.25


Di-(2-ethylhexyl)phthalate (DEHP) may be released from plasticized poly(vinyl chloride) (PVC) articles. In the cases of various methods for the quantitative analysis of migrating DEHP, there are much differences in migrating quantity according to the experimental methods. It is therefore important to make the comparison and analysis between these two results. A study of DEHP migration from blood and infusion bags has been carried out in different methods to evaluate the amount of DEHP migration using gas chromatograph and UV-vis spectrophotometry. Five PVC bags were cut into plane sheets in size of $40{\times}10{\times}0.4mm$, then were immersed in extraction solvent for an hour to release DEHP. It was determined by a gas chromatograph that $23.2{\sim}70.9{\mu}g/mL$ of DEHP was extracted. While extraction solvent was injected into PVC bags which were then placed for an hour to leach DEHP out. It was checked by a UV-vis spectrophotometer that the concentration of DEHP in extraction solvent was $24.8{\sim}41.3{\mu}g/mL$. Two results show different values according to the extraction conditions and experimental methods and the gas chromatographic results were converted into UV-vis spectroscopic results on condition that DEHP would be extracted equally per unit time and unit contact area. It was concluded that DEHP migrating amounts are approximately equal in two analytical methods.


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