Synthesis and Anti-inflammatory Activity of [2-(Benzothiazol-2-ylimino)-4-oxo-3-phenylthiazolidin-5-yl]-acetic Acid Derivatives

  • Sushilkumar S. Bahekar ;
  • Devanand B. Shinde
  • Published : 2003.06.20


A synthetic method for the title compounds (2a-o) was carried out. The title compounds (2a-o)were prepared by the condensation of various thioureas and maleic anhydride. Anti-inflammatory activities in vivo were evaluated and compared with standard drug diclofenac sodium. Some compounds showed moderate activity. The structures of all the new compounds were established on the basis of $^1H$ NMR and IR spectral data.


Anti-Inflammatory; Synthesis; [2-(Benzothiazol-2-ylimino)-4-oxo-3-phenylthiazolidin-5-yl]-acetic Acid; Thiazolidinylacetic Acid


  1. Daniel, Lednicer; Lester A. Mitscher, In Organic Chemistry of Drug Synthesis, John Wiley and Sons,New York, U. S. A., 1980; Vol. 2, p 222.
  2. Andrisano M. G; Di Bella M; Ferrari P; Raffa L; BaggioG. G. Farmaco [Sci] 1981, 36(11), 905.
  3. Sawhney, S. N.; Dhindsa, G. S.; Singh S. P. Indian J.Chemistry 1983, 22B, 1044.
  4. Trivedi J. P.; Contractor S. J.; Shah I. D.; Jour. IndianChem. Soc. 1966, I, 265
  5. Ates O.; Kocabalkanli A.; Sanis G. O.; Ekinci A. C.; Vidin A. Arzneimittelforschung 1997, 47(10),1134.
  6. Tripathi M.; Verma M.; Gujrati V. R.; Palit G.; ShankerK. Arzneimittelforschung 1993, 43(6), 632.
  7. Jury, P. F. In Chemistry and Pharmacology; Edited byR.A. Scherrer and M.W. Whitehouse Academic pressNew York, U. S. A., 1974; Vol. 1, p 92.
  8. Capan G.; Ulusoy N.; Ergenc N.; Cevdet Ekinci A.;Vidin A. Farmaco. 1996, 51(11), 729.
  9. Winter, C. A.; Fisley, E. A.; Nuss, G. W. Proc. Soc.Exp. Biol. Med. 1962, 111, 544.
  10. Kentoro, H.; Hirohiko S. Chem. Pharm. Bull. 1977, 25,2292.
  11. Om Parkash; Shobhna Saini; Neena Saini; Indra Prakash.;Shiv P. Singh; Indian J. Chemistry, 1975, 34(B), 660.
  12. Kocabalkanli A.; Ates O.; Otuk G. Arch Pharm (Weinheim)2001, 334(2), 35.<35::AID-ARDP35>3.0.CO;2-4
  13. Abdel-Rahman R.M. Boll Chim Farm 2001, 140(6),401.

Cited by

  1. Eco-Friendly Synthesis and Insecticidal Activity of Some Fluorinated 2-(N-Arylamino)-4-Arylthiazoles vol.185, pp.7, 2010,
  2. Synthesis and analgesic activity of some acetamide derivatives vol.27, pp.2, 2012,
  3. Synthesis and antimicrobial evaluation of novel 1,3-thiazoles and unsymmetrical azines vol.42, pp.4, 2016,
  4. Synthesis, characterization, structural study and antibacterial activity of the Schiff bases derived from sulfanilamides and related copper(II) complexes vol.453, 2016,