Hepatoprotective Effect of Coccinia indica Against $CCl_4$ Induced Hepatotoxicity

  • Rao, GM Mohana (Pharmacognosy and Ethnopharmacology division, National Botanical Research Institute) ;
  • Vijayakumar, M. (Pharmacognosy and Ethnopharmacology division, National Botanical Research Institute) ;
  • Rao, ChV (Pharmacognosy and Ethnopharmacology division, National Botanical Research Institute) ;
  • Rawat, AKS (Pharmacognosy and Ethnopharmacology division, National Botanical Research Institute) ;
  • Mehrotra, S. (Pharmacognosy and Ethnopharmacology division, National Botanical Research Institute)
  • Published : 2003.03.01

Abstract

The hepatoprotective effect of the ethanolic extract of Coccinia indica fruits in rats treated with carbon tetrachloride. In hepatotoxic rats, liver damage was studied by assessing parameters such as aspartate aminotransferase (AST), alanine aminotransferase (AlT), alkaline phosphatase (AIP) and gamma glutamyl transpeptidase (GGT) in serum, and concentrations of total proteins, total lipids, phospholipids, triglycerides and cholesterol in both serum and liver. The effect of co-administration of ethanolic extract on the above parameters was further investigated. Histopathological study of the liver in experimental animals was also undertaken. Hepatic damage as evidenced by a rise in the levels of AST, AIT, AIP and GGT in serum, and also changes observed in other biochemical parameters In serum and liver showed a tendency to attain near normalcy in animals co-administered with the extract. The normal values for AST (IU/L), AIP (IU/I), protein (g/100 ml) and total lipids (mg/100 ml) in serum (i.e.,20.24, 70.04, 5.72 and 135.54 respectively) were found to alter towards values 32.61, 127.11, 3.83 and 265.91 in hepatotoxic rats. These parameters Attained near normal values (I.e.,22.82, 79.30, 5.22 and 151.24 for AST, AIP protein and total lipids respectively) in ethanolic extract co-administered rats. Profound steatosis, ballooning degeneration and nodule formation observed in the hepatic architecture of $CCl_4$ treated rats were found to acquire near-normalcy in drug co-administered rats, thus corroborating the biochemical observations. Thus the study substantiates the hepatoprotective potential of ethanolic extract of Coccinia indica fruits.

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