Pretective Effect of Purple Sweet Potato (Ipomoea batatas) on Hepatotoxicity Rats Induced by Carbon Tetrachlolide

자색고구마가 사염화탄소 투여에 의한 흰쥐의 간손상 보호에 미치는 영향

  • Kim, Hyeon-A (Department of Food & Nutrition, Mokpo National University) ;
  • Bang, Mi-Ae (Department of Food & Nutrition, Mokpo National University) ;
  • Oh, Yong-Bee (Mokpo Experiment Sta. National Honam Agr. Experiment Sta.) ;
  • Jeong, Byeong-Choon (Mokpo Experiment Sta. National Honam Agr. Experiment Sta.) ;
  • Moon, Youn-Ho (Mokpo Experiment Sta. National Honam Agr. Experiment Sta.) ;
  • Jeong, Woo-Jin (Mokpo Experiment Sta. National Honam Agr. Experiment Sta.) ;
  • Cho, Young-Ja (Department of Food & Nutrition, Mokpo National University)
  • 김현아 (목포대학교 식품영양) ;
  • 방미애 (목포대학교 식품영양) ;
  • 오용비 (호남작물시험장 목포시험장) ;
  • 정병춘 (호남작물시험장 목포시험장) ;
  • 문윤호 (호남작물시험장 목포시험장) ;
  • 정우진 (호남작물시험장 목포시험장) ;
  • 조영자 (목포대학교 식품영양)
  • Published : 2003.06.30

Abstract

The purpose of this study was to investigate the effects of dietary purple sweet potato(Ipomoea batatas) powder on serum lipid levels and antioxidative enzymes in normal and pretective effect on hepatotoxicity rats induced by carbon tetrachlolide. Four groups of rats (3-week-old inbred Sprague-Dawley male rats) were normal rats fed control diet(C), induced hepatotoxicity rats fed control diet(EC), normal rats fed purple sweet potato diet(P), and induced hepatotoxicity rats fed purple potato sweet diet(EP). Rats were induced by single injection of 50% carbon tetrachlolide(0.1 mL/100 g B.W., i.p.). The rats were fed ad libitum each of the experimental diet for 5 weeks. After 5 weeks the rats were sacrificed and activities of antioxidant enzymes and lipid peroxidation products were determined in their liver homogenates. But serum concentrations of lipid was not significant in all groups. Serum alanine aminotransferase(ALT/GPT) and aspartate aminotransferase(AST/GOT) of the EC and EP groups were heigher than the C and P groups. The hepatic glucose 6-phosphatase(G6Pase) activity of the group fed purple potato diet(P) was lower than the other groups(p<0.05). However, The glutathione peroxidase(GPx) activities was not statistically different between the groups. Renal glutathione S-transferase(GST) activity of the EC and EP groups were lower than the C and P groups(p<0.05). In conclusion, these results suggest that purple sweet potato is believed to be possible protective effect on hepatotoxicity rats induced by carbon tetrachlolide.

Keywords

Hepatotoxcity rats;Lipid;GPT;GOT;Antioxidative enzymes

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