Effects of Dried Green Tea Leaf Powder of Serum on Lipid Concentrations in Rats Fed High Fat

녹차 건분이 고지방식이 급여에 의한 흰쥐의 지질 농도에 미치는 영향

  • Published : 2003.06.30

Abstract

The effects of dried green tea leaf powders on serum lipid concentrations were evaluated in rats. Sixty male Sprague-Dawley rats weighing $100{\pm}10g$ were divided into six groups and fed high fat diets for six weeks. Experimental groups were administered with following diets; Normal fat diet and normal and high fat diets with 1% dried green tealeaf powders. Tissue weights of liver, lung, stomach, heart, kidney and spleen of high fat diet exposed rats were reduced by dried green tea leaf powders groups. The concentrations of serum triglyceride in rats fed the dried green tea leaf powders were lower than those in other groups. The concentrations of total cholesterol in green tea leaf powders the were lower than those in high fat diet groups. The concentrations of HDL-cholesterol in serum of the dried leaf powders green tea were significantly higher than those of other groups. The levels of LDL-cholesterol in serum of the dried green tea leaf powders groups were tended to be lower than those of other groups. GPT and GOT were decreased in dried green tea leaf powders groups and than in the high fat group. LDHase was lower in the dried green tea leaf powders groups than in the high fat group. These results suggest that dried leaf powders green tea groups may reduce elevated levels of serum lipid concentrations in rats fed high fat diets.

Keywords

Dried green tea leaf powder;serum lipid concentration;GOT;GPT;LDHase

References

  1. Robak J, Gryglewski RJ. Flavonoids are scavengers of superoxide anions. Biochemical Pharmcology 37: 837-841, 1998 https://doi.org/10.1021/bi972122i
  2. Husain SR, Cillard J, Cillard P. Hydroxyl radical scavenging activity of flavonoids. Phytochemistry 26: 2489-2491, 1987 https://doi.org/10.1016/S0031-9422(00)83860-1
  3. Torsdottir I, Alpsten M, Holm G, Sandberg A-S and Tlli J. A small dose of soluble alginate-fiber affects posrgrandial glycemia and gastric emptying in humans with diaberes. J Nutr 121:795-799, 1991
  4. Chi TH. Natural Antioxidant from Green-tea. Department of Food Science, Rutgars Univ, New Brunswick, NJ 08903, USA
  5. Muramastsu K, Fukuyo M, Hara Y. Effect of green tea catechins on plasma cholesterol level in cholesterol fed rats. J Nutr Sci Vitaminal 2(6): 613-622, 1986
  6. Reitman, S. and Frankel, S. A Colorimetric Method for the Determination of Serum Glutamic Oxalacetic and Glutamic Pyruvic Transaminases. Amer J Clin Pathol 28: 56-60, 1957 https://doi.org/10.1093/ajcp/28.1.56
  7. Muramatsu, Fukuyo M, Hara Y. Effect of green tea catechins on plsma cholesterol level in cholesterolfed rats. J Korean Soc Food Nutr 25(3): 392-398, 1989
  8. Davies, P. and Maloney, A,F.J. Selective loss of cholibergic neurons in alzherimers, disease. Lancet 2: 1403-1407, 1976
  9. Miura Y. Chiba T. Tomita I, Koizumi H, Miura S, Umegaki, K. Hara Y, Lkeda M, Yomita T. Tea catechins prevent the development of atherosclerosis in apoprotein E-deficient mice. J Nutr 131: 27-32, 2001 https://doi.org/10.1093/jn/131.1.27
  10. Osada K, Takahashi M, Hoshina S, Nakamura S, Sugao M. Tea catechins inhibit cholesterol oxidation accompany oxidation of low dendity lipoprotein in vitro. Comp Biochen Physicol C Toxicol Pharmacol 128(2): 153-164, 2001 https://doi.org/10.1016/S1532-0456(00)00192-7
  11. Vinson JA, Dabbagh YA. Effect of green and black tea supplementation on lipids, lipid oxidation and fibrinogen in hamster; Mechanisms for the epidemiological benefits of tea drinking. FEBS Lett 33: 44-46, 1998
  12. Kwon MN, Chol JS and Byun DS. Effect of Flavonoid(+)-eatechin as stabilizer in rat fed fresh and peroxidizes fish oil. J Korean Soc Food Nutr 22(4): 381-391, 1993
  13. Bergmeyer, H.U. Methods of enzymatic analysis. Verlag Chemie, Academic press Weinheim, 1: 20-28, 1974
  14. S Khokhar, SGM Magnusdottir. Total phenol, catechin, and caffein contents of teas commonly consumed in the United Kingdom. J Agric Food Chem 50:565-570, 2002 https://doi.org/10.1021/jf010153l
  15. Yang SC, Wang ZY. Tea and cancer. J Natl Cancer Inst 85: 1038-1049, 1994 https://doi.org/10.1093/jnci/85.13.1038
  16. Oh HM, Min MK : Effects of dried powders, water and ethanol extracts of perimmon and green tea leaves on lipid metabolism and antioxidative capacity on 12-momth-old rats. J Korean Nutr Society 34(33): 285-298, 2001
  17. Yang JL, Suj MJ and Song YS.Effect of dietary fiber on cholesterol metabolism in cholesterolfed rats. J Koean Soc Food Nutr 25(3): 392-398, 1996
  18. Kao YH, Hiipakka RA, Liao S. Modulation of endocrine systems and food intake by green tea epigallocatechin gallate. Endocrinology 141: 481-484, 2000
  19. Chen W-JL. Anderson JW and Fenning D. Propionate May Mediate the hypocho-lesterollemic effect of certain souble plant fibers in cholesterolfed rats. Proc Soc Exp BioI Med 175: 215-218, 1984
  20. Cho YS, Kim CK. Effect of fed of phenolic acids in plant on serum cholesterol concentration in rats. Korean J Food Sci Technol 22(7): 824-827, 1990
  21. Hagulund O, Loustarinen R, Wallin R, Wibell I, Saldeen T. The effect of fish oil on triglycerides, cholesterol, fibrinogen and malondialdehyde in humans supplemented with vitamin. Eur J Nutr 126: 165-172, 1991
  22. Wu JH, Kao JT, Wen MS. Coronary artery disease risk predicted by plasma concentration of HDL cholesterol, apolipoprotein AI, apolipoprotein B, and lipoprotein(a) in a general Chinese population. Clin Chem Clin Chem 39:209-215, 1993
  23. Cohen JC, SchallR. Reassessing the effectsof simple carbohydrates on the serum triglyceride on response to fat meal. Am J din Nutr 4: 1031-1034,1988
  24. Kim ES, Kim MY. Effectsof dried leaf powders and etanol extracts of persimmon, green tea and pine neddle on lipid metabolism and antioxidative capacity in rats Korean J Nutrition 32(4): 337-352, 1999
  25. Park Co Jin SH, Ryu BH. Antioxidant activity of green tea extracts foward Human Low density lipoprotein. 28(5): 850-858, Korean J Soc Food Sci, 1996
  26. Vahouny GV, Khalafi R, Satchithandam S, Watkins DW, Story JA, Cassidy MM and Kritchevsky D. Dietary fiber supplementation and fecal Bile acids Neutral Steroids and divalent cations in rats. J Nutr 117: 2009-2015, 1987 https://doi.org/10.1093/jn/117.12.2009
  27. Ishikawa T, Suzukawa M, Ito T, Yoshida H, Ayaori M, Nishiwaki M, Yonemura A, Nakamura H. Effect of tea flavonoid supplementation on the susceptablity of low-density lipoprotein to oxaidative modification. Am J Clin Nutr 6(2): 261-266, 1997
  28. 2000 Annual Report on the cause of Death Statistics, National Statistics Office. Republic of korea, 2001
  29. Graham HN. Green tea composition, consumption and polyphenol chemisty. Prev Med 21: 334-350, 1999