Screening of Fungal Strains Producing Lovastatin, an Antihypercholesterolemic Agent

콜레스테롤합성저해제 lovastatin을 생산하는 곰팡이 균주의 탐색

  • Published : 2003.06.01

Abstract

Over two hundred fungal strains from Korean soil were tested for the production of cholesterol-lowering agent, lovastatin. Each fungal strain was cultivated in the rapeseedmeal production medium (RPM). After growing for 7 days, the presence of lovastatin in the culture was examined by TLC analysis and HPLC. Nine different fungal strains were determined to produce detectable amounts of lovastatin, among which one fungal strain isolated from barnyard manure of Kanghwa island produced 25.58 mg/L of lovastatin in the production medium. The morphological observation combined with the determination of 18S-rRNA sequence suggested that the selected strain belongs to a member of Aspergillus sp..

Keywords

lovastatin;Aspergillus;cholesterol

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