Physiological Activities of Phellinus ribis Extracts

찔레 영지버섯(Phellinus ribis) 추출물의 생리활성

  • Song, Jae-Hwan (Faculty of Life Science and Technology, Sungkyunkwan University) ;
  • Lee, Hyun-Sook (Faculty of Life Science and Technology, Sungkyunkwan University) ;
  • Hwang, Jin-Kook (Faculty of Life Science and Technology, Sungkyunkwan University) ;
  • Chung, Tae-Young (Faculty of Life Science and Technology, Sungkyunkwan University) ;
  • Hong, Sung-Ryul (Faculty of Life Science and Technology, Sungkyunkwan University) ;
  • Park, Ki-Moon (Faculty of Life Science and Technology, Sungkyunkwan University)
  • 송재환 (성균관대학교 생명공학부) ;
  • 이현숙 (성균관대학교 생명공학부) ;
  • 황진국 (성균관대학교 생명공학부) ;
  • 정태영 (성균관대학교 생명공학부) ;
  • 홍성렬 (성균관대학교 생명공학부) ;
  • 박기문 (성균관대학교 생명공학부)
  • Published : 2003.08.01

Abstract

Physiological activities of 40% ethanol extracts of Phellinus ribis were studied by employing several biological and biochemical assays. The extracts of Phellinus ribis displayed nitrate-scavenging activities (NSA) at pH 1.2 as with 64% NSA with 1.0 mg/mL of the extracts. They also had 91% 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities at the concentration of 1.0 mg/mL. Antioxidant activities of the extracts (at 0.5 mg/mL) on the autoxidation of linoleic acid (p<0.001) were also observed.. The inhibitory effect of the extracts on angiotensin converting enzyme was 11%. Cytotoxic effects of Phellinus ribis extracts against human cancer cell tines were also examined using MTT assay. The extracts (at 50 mg/mL) had severe growth inhibitory effects on A549, Hela, AGS, and SK-Hep-1, which were 8, 44, 76 and 42%, respectively. Ames test indicated that the extracts had no mutating effects on Salmonella typhimurium TA98 and TA100.

Keywords

Phellinus ribis;antioxidant activity;radical scavenging activity;mutagenesis;cytotoxicity

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