A Study on the Longitudinal Bone Growth of Growth-stimulating Material with Eleutherococcus senticosus

가시오가피가 함유된 성장촉진용 조성물의 골성장효과 연구

  • Published : 2003.08.01

Abstract

This study was conducted to evaluate the effect of a growth-stimulating material (GSM) containing Eleutherococcus senticosuson on the longitudinal bone growth. The effects of GSM on proliferation zone and IGF-1 mRNA expression in rat growth plate, IGF-1 mRNA expression in MG-63 osteoblast and Hep-G2 hepatocyte, and bone growth of mouse tibia were studied. GSM significantly increased the proliferation zone in growth plate of proximal tibia (P<0.001) and the IGF-1 mRNA expression in growth plate was also increased (P<0.01). Treatment of GSM to MG-63 osteoblast and Hep-G2 hepatocyte also increased IGF-1 mRNA expression more than twice. In addition, bone mineral density of mouse tibia was significantly increased by GSM (P<0.05). Therefore, it was shown that GSM has an activity of bone growth promotion by increasing the expression of IGF-1, a major bone growth factor.

Keywords

Eleutherococcus senticosuson;growth plate;Hep-G2;IGF-1;MG-63

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