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Effect of Serum IGF-I on Progesterone Concentration during Early Pregnancy in Korean Native Cattle (Hanwoo)

  • Ryu, Yang-Hwan (Department of Animal Science, College of Life and Environmental Sciences Korea University) ;
  • Yang, Jong-Yong (Department of Animal Science, College of Life and Environmental Sciences Korea University) ;
  • Seo, Dong-Sam (Department of Animal Science, College of Life and Environmental Sciences Korea University) ;
  • Ko, Yong (Department of Animal Science, College of Life and Environmental Sciences Korea University)
  • Received : 2002.07.06
  • Accepted : 2002.09.24
  • Published : 2003.02.01

Abstract

Insulin-like growth factor-I (IGF-I) is a polypeptide that has the function of regulating the expression of steroid hormones through endocrine, paracrine, and autocrine actions in reproductive organs. Moreover, IGF-I is involved in ovulation, implantation, maintenance of pregnancy, and development of fetuses in animals. Therefore, this study was conducted to investigate the effects of serum IGF-I concentration on progesterone ($P_4$) concentration and pregnancy rates in Korean native cattle (Hanwoo). Blood was collected at estrus (Day 0) and Day 11. Artificial insemination was performed at Day 0. Serum IGF-I and $P_4$ concentrations were measured by radioimmunoassay (RIA). Overall, $P_4$ concentration was higher at Day 11 than Day 0, whereas the pattern of IGF-I concentration was reversed. When animals were divided into two groups depending on the pregnancy status, $P_4$ concentrations of the pregnant group was significantly higher than that of the non-pregnant group at Day 0 (p<0.05) and Day 11 (p<0.05). But, lower IGF-I concentrations were detected in the pregnant group at Day 0 (p<0.05) and Day 11 (p<0.05) compared to the non-pregnant group. In conclusion, these results indicated that serum IGF-I is inversely associated with $P_4$ concentration during early pregnancy in Hanwoo.

Keywords

IGF-I;Progesterone;Early Pregnancy;Korean Native Cattle

Acknowledgement

Supported by : Korea University

References

  1. Apa, R., F. Miceli, E. Pierro, F. Minici, P. Navarra, A. Caruso, M. Napolitano, S. Mancuso and A. Lanzone. 1999. Paracrine regulation of insulin-like growth factor-I (IGF-I) and IGF-II on prostaglandins $F_{2{\alpha}}$ and $E_2$ synthesis by human corpus luteum in vitro: a possible balance of luteotropic and luteolytic effects. J. Clin. Endocrinol. Metab. 84:2507-2512. https://doi.org/10.1210/jc.84.7.2507
  2. Lee, C. Y. and D. M. Henricks. 1990. Comparisons of various acidic treatments of bovine serum on insulin-like growth factor-I immunoreactivity and binding activity. J. Endocrinology 127:139-148. https://doi.org/10.1677/joe.0.1270139
  3. Lucy, M. C., W. W. Thatcher, R. J. Collier, F. A. Simmen, Y. Ko, J. D. Savio and L. Badinga. 1995. Effects of somatotropin on the conceptus, uterus, and ovary during maternal recognition of pregnancy in cattle. Domest. Anim. Endocrinol. 12:73-82. https://doi.org/10.1016/0739-7240(94)00010-X
  4. Shuichi, K., M. Akio, B. Bajaram and S. Dieter. 2001. Growth hormone, but not luteinizing hormone, acts with luteal peptides on prostaglandin $F2{\alpha}$ and progesterone secretion by bovine copora lutea in vitro. Prostaglandins Other Lipid Mediat. 63:79-92. https://doi.org/10.1016/S0090-6980(00)00099-X
  5. Stewart, R. E., L. J. Spicer, T. D. Hamilton and B. E. Keefer. 1995. Effects of insulin-like growth factor I and insulin on proliferation and on basal and luteinizing hormone-induced steroidogenesis of bovine thecal cells: involvement of glucose and receptors for insulin-like growth factor I and luteinizing hormone. J. Anim. Sci. 73:3719-3731. https://doi.org/10.2527/1995.73123719x
  6. Einspanier, R., A. Miyanoto, D. Schams, M. Muller and G. Brem. 1990. Tissue concentration, RNA expression and stimulation of IGF-I in luteal tissue during the oestrus cycle pregnancy of cows. J. Reprod. Fertil. 90:439-445. https://doi.org/10.1530/jrf.0.0900439
  7. Nicholson, W. C., Z. Ge, D. M. Plotner, C. E. Farin and J. E. Gadsby. 1999. Insulin-like growth factor (IGF)-I, IGF-I receptor, and IGF binding protein-3 messenger ribonucleic acids and protein in corpora lutea from prostaglandin $F_{2{\alpha}}$-treated gilts. Biol. Reprod. 61:1527-1534. https://doi.org/10.1095/biolreprod61.6.1527
  8. Khan-Dawood, F. S., R. Gargiulo and M. Dawood. 1994. In vitro microdialysis of the ovine corpus luteum of the ovine corpus luteum of pregnancy: effects of insulin-like growth factor on progesterone secretion. Biol. Reprod. 51:1299-1306. https://doi.org/10.1095/biolreprod51.6.1299
  9. Constantino, C. X., P. L. Keyes and J. L. Kostyo. 1991. Insulinlike growth factor-I stimulates steroidogenesis in rabbit luteal cells. Endocrinology 128:1702-1708. https://doi.org/10.1210/endo-128-4-1702
  10. Yun, J. S., W. J. Kang, D. S. Seo, S. S. Park, K. C. Hong, C. Y. Lee and Y. Ko. 2000. Association of endocrine factors (insulin-like growth factor-II and binding protein-3) with litter size in pigs. Asian-Aust. J. Anim. Sci. 14:307-315.
  11. Daughaday, W. H., I. K. Mariz and S. L. Blethen. 1980. Inhibition of access of bound somatomedin to membrane receptor and immunobinding sites: a comparison of radioreceptor and radioimmunoassay of somatomedin in native and acidicethanol-extracted serum. J. Clin. Endocrinol. Metab. 51:781-788. https://doi.org/10.1210/jcem-51-4-781
  12. Luigi, D., K. Paulina, C. Olga, V. Margarita, L. T. Jose and C. Eduardo. 1995. Multihormonal regulation of progesterone synthesis in cultured human midluteal cells. J. Clin. Endocrinol. Metab. 80:1566-1570. https://doi.org/10.1210/jc.80.5.1566
  13. Sayre, B. L., R. Traft, E. K. Inskeep and J. Killefer. 2000. Increased expression of insulin-like growth factor binding protein-1 during induced regression of bovine corpora lutea. Biol. Reprod. 63:21-29. https://doi.org/10.1095/biolreprod63.1.21
  14. Csapo, A. I., M. O. Pulkkinen and W. G. Wiest. 1973. Effects of lutectomy and progesterone replacement therapy in early pregnant patients. Am. J. Obstet. Gynecol. 115:759-765. https://doi.org/10.1016/0002-9378(73)90517-6
  15. Lievermann, J., D. Schams and A. Miyamoto. 1996. Effects of local growth factors on the secretory function of bovine corpus luteum during the oestrus cycle and pregnancy in vitro. Reprod. Fertil. Dev. 8:1003-1011. https://doi.org/10.1071/RD9961003
  16. McWilliam, R., R. E. Leake and J. R. Coutts. 1995. Growth factors in human ovarian follicle fluid and growth factor receptors in granulosa-luteal cells. Int. J. Biol. Markers. 10:216-220.
  17. Tamada, H., H. Kitashin, T. Sawada and J. Mori. 1995. Expression of insulin-like growth factor I mRNA in rat luteal tissue increases with functional regression of the corpus luteum. Prostaglandin 50:151-160. https://doi.org/10.1016/0090-6980(95)00106-9
  18. Watson, A. J., M. E. Westhusin and Q. A. Winger. 1999. IGF paracrine and autocrine interactions between conceptus and oviduct. J. Reprod. Fertil. Suppl. 54:303-315.
  19. Apa, R., N. Di Simone, E. Ronsisvalle, F. Miceli, D. de Fed, A. Caruso, A. Lanzone and S. Mancuso. 1996. Insulin-like growth factor (IGF)-I and IGF-II stimulate progesterone production by human luteal cells: role of IGF-I as mediator of growth hormone action. Fertil. Steril. 66:235-239. https://doi.org/10.1016/S0015-0282(16)58445-3
  20. Kapur, S., H. Tamada, S. K. Dey and G. K. Andrews. 1992. Expression of insulin-like growth factor-I (IGF-I) and its receptor in the peri-implantation mouse uterus, and cellspecific regulation of IGF-I gene expression by estradiol and progesterone. Biol. Reprod. 46:208-219. https://doi.org/10.1095/biolreprod46.2.208
  21. Yuan, W. and M. C. Lucy. 1996. Effects of growth hormone, prolactin, insulin-like growth factors, and gonadotropins on progesterone secretion by porcine luteal cells. J. Anim. Sci. 74:866-872. https://doi.org/10.2527/1996.744866x
  22. Rotwein, P. 1991. Structure, evolution, expression and regulation of insulin-like growth factors I and II. Growth Factors 5:3-18. https://doi.org/10.3109/08977199109000267
  23. Hashizume, T., K. Ohtsuki and N. Matsumoto. 2000. Serum insulin-like growth factor-I concentrations increase during the estrous phase in goats. Domest. Anim. Endocrinol. 18:253-263. https://doi.org/10.1016/S0739-7240(99)00082-X
  24. Chen, S. H., V. Zanagnolo, S. Preutthipan, K. P. Roberts, S. B. Goodman and A. M. Dharmarajan. 1997. The role of insulinlike growth factor-I (IGF-I) and estradiol in rabbit corpus luteum progesterone production. Endocrine 6:73-77. https://doi.org/10.1007/BF02738805
  25. Sarvas, K., M. Angervo, R. Koistinen, A. Tiiinen and M. Seppala. 1994. Prostaglandin $F_{2{\alpha}}$ stimulate release of insulin-like growth factor binding protein-3, from cultured human granolos-luteal cells. Horm. Reprod. 1643-16496.
  26. SAS. 1995. SAS/STAT Software for PC. Release 6.11, SAS Institute, Cary, NC, USA.