Effect of Serum IGF-I on Progesterone Concentration during Early Pregnancy in Korean Native Cattle (Hanwoo)

  • Ryu, Yang-Hwan (Department of Animal Science, College of Life and Environmental Sciences Korea University) ;
  • Yang, Jong-Yong (Department of Animal Science, College of Life and Environmental Sciences Korea University) ;
  • Seo, Dong-Sam (Department of Animal Science, College of Life and Environmental Sciences Korea University) ;
  • Ko, Yong (Department of Animal Science, College of Life and Environmental Sciences Korea University)
  • Received : 2002.07.06
  • Accepted : 2002.09.24
  • Published : 2003.02.01


Insulin-like growth factor-I (IGF-I) is a polypeptide that has the function of regulating the expression of steroid hormones through endocrine, paracrine, and autocrine actions in reproductive organs. Moreover, IGF-I is involved in ovulation, implantation, maintenance of pregnancy, and development of fetuses in animals. Therefore, this study was conducted to investigate the effects of serum IGF-I concentration on progesterone ($P_4$) concentration and pregnancy rates in Korean native cattle (Hanwoo). Blood was collected at estrus (Day 0) and Day 11. Artificial insemination was performed at Day 0. Serum IGF-I and $P_4$ concentrations were measured by radioimmunoassay (RIA). Overall, $P_4$ concentration was higher at Day 11 than Day 0, whereas the pattern of IGF-I concentration was reversed. When animals were divided into two groups depending on the pregnancy status, $P_4$ concentrations of the pregnant group was significantly higher than that of the non-pregnant group at Day 0 (p<0.05) and Day 11 (p<0.05). But, lower IGF-I concentrations were detected in the pregnant group at Day 0 (p<0.05) and Day 11 (p<0.05) compared to the non-pregnant group. In conclusion, these results indicated that serum IGF-I is inversely associated with $P_4$ concentration during early pregnancy in Hanwoo.


IGF-I;Progesterone;Early Pregnancy;Korean Native Cattle


Supported by : Korea University


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