Effects on EDC-like farming chemicals in aquatic Organism

환경생물에 대한 내분비교란물질 의심 농약의 영향

  • Kim, Hyun-Woo (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University) ;
  • Park, Kun-Ho (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University) ;
  • Park, Jin-Hong (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University) ;
  • Jin, Hua (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University) ;
  • Kim, Joon-Seong (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University) ;
  • Eu, Gook-Jong (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University) ;
  • Cho, Hyun-Sun (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University) ;
  • Kang, Ga-Mi (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University) ;
  • Lee, Myung-Sung (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University) ;
  • Song, Byung-Hoon (Pesticide Safety Division, Department of Crop Protection, National Institute of Agricultural Science & Technology) ;
  • Shin, Jin-Sup (Pesticide Safety Division, Department of Crop Protection, National Institute of Agricultural Science & Technology) ;
  • Cho, Maing-Haing (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University)
  • 김현우 (서울대학교 수의과대학 독성학교실) ;
  • 박건호 (서울대학교 수의과대학 독성학교실) ;
  • 박진홍 (서울대학교 수의과대학 독성학교실) ;
  • 김화 (서울대학교 수의과대학 독성학교실) ;
  • 김준성 (서울대학교 수의과대학 독성학교실) ;
  • 유국종 (서울대학교 수의과대학 독성학교실) ;
  • 조현선 (서울대학교 수의과대학 독성학교실) ;
  • 강가미 (서울대학교 수의과대학 독성학교실) ;
  • 이명성 (서울대학교 수의과대학 독성학교실) ;
  • 송병훈 (농업과학기술원 작물보호부 농약안전성과) ;
  • 신진섭 (농업과학기술원 작물보호부 농약안전성과) ;
  • 조명행 (서울대학교 수의과대학 독성학교실)
  • Published : 2003.09.30

Abstract

Endocrine disrupting chemicals (EDCs) can alter hormone regulation that control reproductive system in animals. The effects of endosulfan, molinate, and alachlor that suspected to have examined disruption EDCs effect on a fish species of interest, Xiphophorus helleri (swordtail fish), were studied using vitellogenin (Vtg) and aromatase as diagnostic biomarkers. Induction of Vtg proteins was detected by RT-PCR in male fish treated with alachlor, and mixture of endosulfan and molinate in dose response manner. Also, induction of aromatase was detected by RT-PCR in male fish treated with alachlor, endosulfan, and mixture of endosulfan and molinate in sinlilar manner. In this study, swordtail fish exposed to endosulfan or molinate individually did not show any adverse effects. However, Vtg and aromatase expressions and apoptosis were detected in swordtail. fish exposed to the mixture of endosulfan and molinate. These results suggested that low concentrations of mixture of molinate and endosulfan individually do not affect swordtail fish, but may influence genital system, and induce apoptosis.

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