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양파로부터 분리한 생리활성분획이 생리활성 및 지질대사에 미치는 영향

Effect of Biologically Active Fractions from Onion on Physiological Activity and Lipid Metabolism

  • 우희섭 (동주대학 식품과학계열) ;
  • 안봉전 (경산대학교 생명자원공학부) ;
  • 배종호 (대구미래대학 제과데코레이션과) ;
  • 김성 (영남대학교 생물산업공학부) ;
  • 최희진 (영남대학교 생물산업공학부) ;
  • 한호석 (영남대학교 생물산업공학부) ;
  • 최청 (영남대학교 생물산업공학부)
  • Woo, Hi-Seob (School of Food Science, Dongju College) ;
  • Aan, Bong-Jeun (Faculty of Life Resources and Engineering, Kyungsan University) ;
  • Bae, Jong-Ho (Dept. of Confectionary Decoration, Daegu Future College) ;
  • Kim, Sung (Dept. of Food Science and Technology, Yeungnam University) ;
  • Choi, Hee-Jin (Dept. of Food Science and Technology, Yeungnam University) ;
  • Han, Ho-Suk (Dept. of Food Science and Technology, Yeungnam University) ;
  • Choi, Cheong (Dept. of Food Science and Technology, Yeungnam University)
  • 발행 : 2003.02.01

초록

양파를 80% ethanol로 추출하여 Sephadek LH-20 column chromatography로 fraction I, II 및 III의 생리활성물질을 분리하여 angiotensin converting enzyme(ACE), xanthine oxidase, tyrosinase의 저해작용 효과와 지질대사를 검토하였다 Fraction I과 II의 ACE 저해작용은 50 ppm 농도에서 80% 이상의 효소 저해효과를 나타내었고 fraction III에서는 500 ppm 농도에서 90% 효소저해작용을 보였다. 100 ppm 농도에서 fraction III의 xantine oxidase 효소저해 효과는 82.5%로 나타났으며 tyrosinase의 저해효과는 42.6%이었다. 효소저해작용이 가장 강한 fraction III를 2개월 동안 고지방식이에 첨가하여 혈장 및 간장에서 지질대사에 미치는 영향을 분석한 결과 혈장에서는 총지질, 중성지질이 대조군에 비하여 유의성 있게 감소하였다. 간의 콜레스테롤량도 약 50% 정도 감소하는 결과를 얻었다.

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피인용 문헌

  1. Effect of Onion Extracts on Serum Cholesterol in Borderline Hypercholesterolemic Participants vol.39, pp.12, 2010, https://doi.org/10.3746/jkfn.2010.39.12.1783
  2. The effect of onion on hyperlipidemia: Meta-analysis vol.23, pp.6, 2012, https://doi.org/10.7465/jkdi.2012.23.6.1103
  3. Effects of Onion Peel Water Extract on the Blood Lipid Profiles in Mice Fed a High-Fat Diet vol.22, pp.3, 2014, https://doi.org/10.7783/KJMCS.2014.22.3.203