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재래식 버섯균사체 된장의 항종양성과 항돌연변이성

Enhanced Antitumorigenicity and Antimutagenicity of Doenjang Prepared from Mushroom Mycelia-cultured Traditional Mejus

  • 김석종 (경상대학교 응용생명과학부) ;
  • 박철우 (경상대학교 응용생명과학부) ;
  • 박숙자 (경상대학교 응용생명과학부) ;
  • 김영숙 (경상대학교 응용생명과학부) ;
  • 조현종 (농협중앙회 식품연구소) ;
  • 임동길 (부산지방식품의약품안전청) ;
  • 김정옥 (㈜ HK 바이오텍) ;
  • 이주희 (경상대학교 식품영양학과) ;
  • 하영래 (경상대학교 응용생명과학부)
  • 발행 : 2003.02.01

초록

재래식 버섯균사체메주로부터 제조된 재래식 버섯균사체 된장의 항종양성, 항산화성 및 항돌연변이성을 연구하였다. 항종양성 (S-180 세포로 유발한 mouse ascites cancer) 에서는 느타리, 영지, 상황, 신령 버섯균사체 된장이 각각 33, 30, 26, 25% 억제하여 재래식 된장(11%)에 비해 매우 우수한 항종양성을 나타내었다. 버섯균사체 된장은 S. typhimurium TA98에 대한 IQ와 AFB$_1$에 의한 돌연변이성을 각각 39.7~46.1%, 38.0~39.7% 억제하여 대조된장(32.0, 33.2%)에 비해 항돌연변이성이 우수하였다. S. fyphimurium TA 100에 대해서는 IQ와 AFB$_1$의 돌연변이성을 각각 31.9~35.6%, 24.9~30.4% 억제하여 대조된장(27.5, 22.5%)에 비해 항돌연변이성이 좋았다. 항산화성 역시 버섯균사체된장이 대조된장에 비해 효과가 우수하였다 관련 물질로서 $\beta$-D-g1ucan 함량은 버섯균사체된장의 경우 재래식 된장에 비하여 3~8배, 총 Phenol성 화합물과 isoflavone 함량은 느타리버섯균사체된장과 신령버섯균사체가 가장 높았다.

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피인용 문헌

  1. Inhibition of Free Radical-Induced Lipid Oxidation by the Extract from Submerged-Liquid Culture of Mushrooms in the Medium Containing Mulberry Tree Powders vol.33, pp.2, 2004, https://doi.org/10.3746/jkfn.2004.33.2.255
  2. Inhibition of Lipid Autoxidation by the Extract of the Submerged-liquid Culture of Mushrooms in the Medium Containing Mulberry Tree Powders vol.33, pp.2, 2004, https://doi.org/10.3746/jkfn.2004.33.2.249