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Inhibition of Tumor Growth through Macrophage Activation by Polysaccharide Fraction from Peonia japonica (PJ-P)

백작약 조다당분획에 의한 대식세포 활성화를 통한 암세포 증식 억제

  • 박혜란 (한국원자력연구소 방사선식품생명공학기술개발팀) ;
  • 정우희 (한국원자력연구소 방사선식품생명공학기술개발팀) ;
  • 정일윤 (한국원자력연구소 방사선식품생명공학기술개발팀) ;
  • 이성태 (순천대학교 생물학과) ;
  • 조성기 (한국원자력연구소 방사선식품생명공학기술개발팀)
  • Published : 2003.02.01

Abstract

The immunomodulatory activity of PJ-P, a polysaccharide fraction extracted from Paeonia japonica, were reported in our previous paper. In the present study, we investigated that PJ-P inhibited cancer growth through activation of macrophages. The activities of peritoneal macrophage to induce tumor necrosis factor (TNF)-$\alpha$, interleukin-1 (IL-1)$\beta$, interleukin-6 (IL-6) and interleukin-12 (IL-12) as well as to ingest fluorescence-latex microbeads were enhanced by treatment of PJ-P. Direct cytocidal activity of PJ-P against cancer cells was not shown. However, in vitro, peritoneal macrophages treated with PJ-P had an activity to kill cancer cells. Furthermore, PJ-P significantly prolonged the survival of mice implanted intraperitoneally with B16F0 mel-anoma cells. These results suggest that PJ-P could be a useful immunomodulator and assistant of anti-tumor agent.

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