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홍국 장기투여가 SHR의 혈압 및 혈중 콜레스테롤 조성에 미치는 영향

Effect of Monascus koji on Blood Pressure and Serum Cholesterol Composition of SHR by Chronic Dietary Administration

  • 류미라 (한국식품개발연구원) ;
  • 김은영 (한국식품개발연구원) ;
  • 한진수 (㈜바이오제노믹스 해은생명과학연구소)
  • 발행 : 2003.04.01

초록

홍국의 장기섭취가 자연발증 고혈압 쥐(SHR)의 혈압상승 및 혈중 콜레스테롤 조성에 미치는 영향을 조사하였다. Monascus ruber IFO 32318 균주로 제조한 홍국을 각각 0.03%, 0.1%, 0.3% 첨가한 식이를 8주간 섭취시킨 후 모든 실험군을 일반식이로 전환시켜 다시 2주간 사육하였다. 식이섭취 2주 째부터 대조군에 비해 홍국 섭취군에서 수축기혈압, 이완기 혈압 및 평균혈압의 유의적인 상승 억제효과가 나타났으며 그 효과는 식이에 첨가된 홍국의 양에 비례하였고 홍국첨가 식이를 중단하면 실험군 간의 각 혈압의 유의적인 차이는 사라졌다. 또한 홍국은 SHR의 혈중 VLDL-C의 함량을 유의적으로 저하시켰으며 TC 및 LDL-C은 홍국 첨가량이 많을수록 낮은 경향을 나타내었고 HDL-C은 대조군, group I 및 group II가 거의 동일하였으며 홍국 첨가량이 가장 많은 group III에서만 약간 높은 경향을 나타내었다. 또한 동맥경화의 지표가 되는 TC과 HDL-C의 비율 및 non-HDL-C과 HDL-E의 비율은 홍국 섭취량이 증가할수록 감소하는 경향을 보였고 LDL-C과 HDL-C의 비율 또한 홍국 섭취군이 대조군보다 유의적으로 낮은 값을 나타내었다. 이러한 모든 효과는 홍국을 식이 섭취량의 0.1% 이상 첨가한 실험군에서 뚜렷이 나타났다.

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  2. The Effect of Rice with Aspergillus terreus on Lipid Metabolism in Rats vol.47, pp.5, 2015, https://doi.org/10.9721/KJFST.2015.47.5.658
  3. Effect of Red Yeast (Monascus purpureus) Rice Supplemented Diet on Lipid Profiles and Antioxidant Activity in Hypercholesterolemic Rats vol.43, pp.1, 2014, https://doi.org/10.3746/jkfn.2014.43.1.016