In-Vivo Heat Transfer Measurement using Proton Resonance Frequency Method of Magnetic Resonance Imaging

자기 공명영상 시스템의 수소원자 공명 주파수법을 이용한 생체 내 열 전달 관찰

  • 조지연 (인제대학교 의용공학과) ;
  • 조종운 (인제대학교 의용공학과) ;
  • 이현용 (부산백병원 진단방사선과) ;
  • 신운재 (부산백병원 진단방사선과) ;
  • 은충기 (인제대학교 의과대학 진단방사선과) ;
  • 문치웅 (인제대학교 의용공학과)
  • Published : 2003.05.01

Abstract

The purpose of this study is to observe the heat transfer process in in-vivo human muscle based on Proton Resonance Frequency(PRF) method in Magnetic Resonance Imaging(MRI). MRI was obtained to measure the temperature variation according to the heat transfer in phantom and in-vivo human calf muscle. A phantom(2% agarose gel) was used in this experiment. MR temperature measurement was compared with the direct temperature measurement using a T-type thermocouple. After heating agarose gel to more than 5$0^{\circ}C$ in boiling hot water, raw data were acquired every 3 minutes during one hour cooling period for a phantom case. For human study heat was forced to deliver into volunteer's calf muscle using hot pack. Reference data were once acquired before a hot pack emits heat and raw data were acquired every 2 minutes during 30minutes. Acquired raw data were reconstructed to phase-difference images with reference image to observe the temperature change. Phase-difference of the phantom was linearly proportional to the temperature change in the range of 34.2$^{\circ}C$ and 50.2$^{\circ}C$. Temperature resolution was 0.0457 radian /$^{\circ}C$(0.0038 ppm/$^{\circ}C$) in phantom case. In vivo-case, mean phase-difference in near region from the hot pack is smaller than that in far region. Different temperature distribution was observed in proportion to a distance from heat source.

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