DOI QR코드

DOI QR Code

Effect of Chromium Methionine Supplementation on Obesity Index and Serum Lipids in Rats

Chromium Methionine첨가가 비만지수 및 지질 대사에 미치는 영향

  • Kim, Hyun-Sook (Institute of Animal Resources, Kangwon National University) ;
  • Lee, Sun-Yeon (Institute of Animal Resources, Kangwon National University) ;
  • Kim, Chang-Hyeuk (Institute of Animal Resources, Kangwon National University) ;
  • Ohh, Sang-Jip (Institute of Animal Resources, Kangwon National University) ;
  • Shin, Jong-Seo (Institute of Animal Resources, Kangwon National University) ;
  • Sung, Kyung-Il (Institute of Animal Resources, Kangwon National University)
  • 김현숙 (강원대학교 동물자원공동연구소) ;
  • 이선연 (강원대학교 동물자원공동연구소) ;
  • 김창혁 (강원대학교 동물자원공동연구소) ;
  • 오상집 (강원대학교 동물자원공동연구소) ;
  • 신종서 (강원대학교 동물자원공동연구소) ;
  • 성경일 (강원대학교 동물자원공동연구소)
  • Published : 2003.07.01

Abstract

Chromium (Cr) plays an important role in body composition. Several human and animal studies of Cr supplementation have reported increases in lean body mass, often with concurrent decreases in body fat. The purpose of the current study was to determine the effects of supplemental Cr as chromium methionine (CrMet) on obesity index, body fat and serum lipids in rats. Thirty-six male Sprague-Dawley rats were divided into four groups of nine rats. Rats received a AIN-76 semipetrified basal diet or high fat diet supplemented with 300 ppb CrCl$_3$and CrMet as well as no added dietary Cr (referred to as Control, HF, HFCr, and HFCrMet). After 6 weeks on the respective diets, animals were killed and analyzed for differences in serum lipid concentrations. Rats supplemented with CrMet had a slightly higher naso-anal length and final body weight was decreased. The lowest obesity index and body fat content were found in CrMet supplemented animals (p〈0,05). Supplemental CrMet decreased the total lipid, triglyceride and total cholesterol. The significant differences observed were total cholesterol concentration for CrMet supplementation. These indicate that supplemental Cr, as chromium methionine, resulted in a significant decrease of obesity index and body fat and influence serum lipid concentrations, possibly by decreasing the body fat.

References

  1. Forbes RM, Erdman JW. 1983. Bioavailability of trace mineral elements. Ann Rev Nutr 3: 213-221 https://doi.org/10.1146/annurev.nu.03.070183.001241
  2. Mertz W. 1967. Biological role of chromium. Fed Proc 26:189-193
  3. Schoreder HA. 1968. The role of chromium in mammaliannutrition. Am J Clin Nutr 21: 230-244
  4. Anderson RA. 1987. Trace elements in human and animalnutrition. 5th ed. Academic Press, New York. p 225
  5. Casparwenk. 1995. Organic chromium in growing pigs: Observations following a year of use and research in Switzerland. Proceedings of Alltech's 12th Annual Symposium. Nottingham, UK. p 301-308
  6. Mowat DN. 1993. Organic chromium: A new nutrient forstressed animals. Proceedines of Alltech's 10th Annual Symposium. Nottingham, UK. p 275
  7. Kornegay ET, Wang Z, Wood CM, Lindermann MD. 1997. Supplemental chromium picolinate influences nitrogen balance, dry matter digestibility, and carcass traits in growing-finishing pigs. J Animal Sci 75: 1319-1323 https://doi.org/10.2527/1997.7551319x
  8. Page TG, Southern LL, Ward TL, Thompson DL. 1993. Effect of chromium picolinate on growth and serum and carcass traits of growing-finishing pigs. J Anim Sci 71: 656-662 https://doi.org/10.2527/1993.713656x
  9. Evans GW. 1989. The effect of chromium picolinate on insulin controlled parameters in humans. Int J Biosocial Med Res 11: 163-180
  10. Hasten DL, Hegsted M, Keenan MJ, Morris GS. 1997. Dosage effects of chromium picolinate on growth and body composition in the rat. Nutr Res 17: 1175-1186 https://doi.org/10.1016/S0271-5317(97)00088-2
  11. Hasten DL, Rome EP, Franks BD, Hegsted M. 1992. Effectsof chromium picolinate on beginning weight training students. Int J Sport Nutr 2: 343-350 https://doi.org/10.1123/ijsn.2.4.343
  12. Mertz W, Roginski EE. 1969. Effect of $Cr^{3+}$ supplement ongrowth and survival under stress in rats fed low proteindiets. J Nutr 947: 531-536
  13. Mertz W, Roginski EE. 1975. Some biological properties ofchromium (Cr)-nicotinic acid (NA) complexes. Fed Proc 34:992 (abstract)
  14. Kegley EB, Galloway DL, Fakler TM. 2000. Effect of dietary chromium-L-methionine on glucose metabolism ofbeef steers. J Anim Sci 78: 3177-3183 https://doi.org/10.2527/2000.78123177x
  15. Dubuc PU. 1981. Non-essential role of dietary factors in thedevelopment of diabetes in ob/ob mice. J Nutr 111: 1742-1748
  16. Tsuchimoto M, Miyata K, Matsuo S, Osato S, Kora H,Misima T, Tachibana K. 1992. Relationship between bodyfat content and body density in cultured red Sea bream. Nippon Suison Gakkaishi 58: 301-306 https://doi.org/10.2331/suisan.58.301
  17. Mooney KW, Cromwell GL. 1995. Effects of dietary chro-mium picolinate supplementation on growth, carcass Characteristics, and accretion rates of carcass tissues in growing-finishing swine. J Anim Sci 73: 3351-3357 https://doi.org/10.2527/1995.73113351x
  18. Riales R, Albrink MJ. 1981. Effect of chromium chloridesupplementation on glucose tolerance and serum lipidsincluding high density lipoprotein of adult men. Am J Clin Nutr 34: 2670-2678
  19. Mossop RT. 1983. Effects of chromium Ⅲ on fasting glucose, cholesterol and HDL cholesterol in diabetes. Cent Afr Med 29: 80-82
  20. Mertz W. 1969. Chromium occurrence and function in biological systems. Physiol Rev 49: 163-239
  21. Offenbacher EG, Pi-Sunyer FX. 1988. Chromium in humannutrition. Ann Rev Nutr 8: 543-563 https://doi.org/10.1146/annurev.nu.08.070188.002551
  22. Schroeder HA, Nason AP, Tipton IH. 1970. Chromiumdeficiency as a factor in atherosclerosis. J Chronic Dis 23:123-142 https://doi.org/10.1016/0021-9681(70)90071-8
  23. Abraham AS, Sonnenblick M, Eini M, Shemesh O, Batt AP. 1980. The effect of chromium on established atherosclerotic plaques in rabbits. Am J Clin Nutr 33: 2294-2298
  24. Press RI, Geller J, Evans GW. 1990. The effect of chromium picolinate on cholesterol and apolipoprotein fractions inhuman subjects. Western J Med 152: 41-45
  25. Kritchevsky D. 1987. Inhibition of cholesterol synthesis. J Nutr 117: 1330-1334
  26. Holdsworth ES, Kaufman DV, Neville E. 1991. A fractionderived from brewer's yeast inhibits cholesterol synthesisby rat liver preparations in vitro. British J Nutr 65: 285-299 https://doi.org/10.1079/BJN19910087

Cited by

  1. Effects of the Red Garlic Extract for Anti-Obesity and Hypolipidemic in Obese Rats Induced High Fat Diet vol.21, pp.2, 2011, https://doi.org/10.5352/JLS.2011.21.2.211